node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADH1A | CES5A | ENSP00000209668 | ENSP00000428864 | alcohol dehydrogenase 1A (class I), alpha polypeptide | carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity) | 0.514 |
ADH1A | ESD | ENSP00000209668 | ENSP00000367992 | alcohol dehydrogenase 1A (class I), alpha polypeptide | esterase D; Serine hydrolase involved in the detoxification of formaldehyde | 0.856 |
ADH1B | CES5A | ENSP00000306606 | ENSP00000428864 | alcohol dehydrogenase 1B (class I), beta polypeptide | carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity) | 0.459 |
ADH1B | ESD | ENSP00000306606 | ENSP00000367992 | alcohol dehydrogenase 1B (class I), beta polypeptide | esterase D; Serine hydrolase involved in the detoxification of formaldehyde | 0.859 |
ADH4 | ADH7 | ENSP00000265512 | ENSP00000420269 | alcohol dehydrogenase 4 (class II), pi polypeptide | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism | 0.591 |
ADH4 | CES5A | ENSP00000265512 | ENSP00000428864 | alcohol dehydrogenase 4 (class II), pi polypeptide | carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity) | 0.490 |
ADH4 | ESD | ENSP00000265512 | ENSP00000367992 | alcohol dehydrogenase 4 (class II), pi polypeptide | esterase D; Serine hydrolase involved in the detoxification of formaldehyde | 0.865 |
ADH4 | UBC | ENSP00000265512 | ENSP00000344818 | alcohol dehydrogenase 4 (class II), pi polypeptide | ubiquitin C | 0.591 |
ADH5 | CES5A | ENSP00000296412 | ENSP00000428864 | alcohol dehydrogenase 5 (class III), chi polypeptide; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione | carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity) | 0.745 |
ADH5 | ESD | ENSP00000296412 | ENSP00000367992 | alcohol dehydrogenase 5 (class III), chi polypeptide; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione | esterase D; Serine hydrolase involved in the detoxification of formaldehyde | 0.989 |
ADH5 | UBC | ENSP00000296412 | ENSP00000344818 | alcohol dehydrogenase 5 (class III), chi polypeptide; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione | ubiquitin C | 0.923 |
ADH6 | CES5A | ENSP00000378359 | ENSP00000428864 | alcohol dehydrogenase 6 (class V) | carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity) | 0.527 |
ADH6 | ESD | ENSP00000378359 | ENSP00000367992 | alcohol dehydrogenase 6 (class V) | esterase D; Serine hydrolase involved in the detoxification of formaldehyde | 0.859 |
ADH7 | ADH4 | ENSP00000420269 | ENSP00000265512 | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism | alcohol dehydrogenase 4 (class II), pi polypeptide | 0.591 |
ADH7 | CES5A | ENSP00000420269 | ENSP00000428864 | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism | carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity) | 0.569 |
ADH7 | ESD | ENSP00000420269 | ENSP00000367992 | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism | esterase D; Serine hydrolase involved in the detoxification of formaldehyde | 0.854 |
CES5A | ADH1A | ENSP00000428864 | ENSP00000209668 | carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity) | alcohol dehydrogenase 1A (class I), alpha polypeptide | 0.514 |
CES5A | ADH1B | ENSP00000428864 | ENSP00000306606 | carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity) | alcohol dehydrogenase 1B (class I), beta polypeptide | 0.459 |
CES5A | ADH4 | ENSP00000428864 | ENSP00000265512 | carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity) | alcohol dehydrogenase 4 (class II), pi polypeptide | 0.490 |
CES5A | ADH5 | ENSP00000428864 | ENSP00000296412 | carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity) | alcohol dehydrogenase 5 (class III), chi polypeptide; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione | 0.745 |