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ABTB2 ABTB2 ALKBH4 ALKBH4 ALKBH5 ALKBH5 ALKBH6 ALKBH6 BTBD11 BTBD11 ALKBH1 ALKBH1 ALKBH3 ALKBH3 ALKBH7 ALKBH7 FTO FTO ALKBH2 ALKBH2
"ALKBH6" - alkB, alkylation repair homolog 6 (E. coli) in Homo sapiens
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Predicted Interactions
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Score
ALKBH6alkB, alkylation repair homolog 6 (E. coli); Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity) (266 aa)    
Predicted Functional Partners:
ALKBH1
alkB, alkylation repair homolog 1 (E. coli); Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron (389 aa)
            score_image   0.868
ALKBH4
alkB, alkylation repair homolog 4 (E. coli); Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity) (302 aa)
            score_image   0.789
ALKBH3
alkB, alkylation repair homolog 3 (E. coli); Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron (286 aa)
            score_image   0.704
ALKBH5
alkB, alkylation repair homolog 5 (E. coli); Dioxygenase that demethylates RNA by oxidative demethylation- specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m(6)A mRNA affects mRNA processing and export and is required for spermatogenesis (394 aa)
            score_image   0.660
ABTB2
ankyrin repeat and BTB (POZ) domain containing 2; May be involved in the initiation of hepatocyte growth (By similarity) (1025 aa)
        score_image   score_image   0.571
BTBD11
BTB (POZ) domain containing 11 (1104 aa)
        score_image   score_image   0.571
ALKBH7
alkB, alkylation repair homolog 7 (E. coli); Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity) (221 aa)
            score_image   0.504
ALKBH2
alkB, alkylation repair homolog 2 (E. coli); Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1- ethenoadenine (in vitro). Has strong preference for double- stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron (261 aa)
            score_image   0.481
FTO
fat mass and obesity associated; Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single- stranded RNA containing 3-methyluracil, followed by single- stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and ener [...] (505 aa)
            score_image   0.441
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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