node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGPAT6 | AGPAT9 | ENSP00000380184 | ENSP00000264409 | 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta); Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long- chain fatty acyl-CoAs | 1-acylglycerol-3-phosphate O-acyltransferase 9; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Overexpression activates the mTOR pathway | 0.901 |
AGPAT6 | GK | ENSP00000380184 | ENSP00000368226 | 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta); Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long- chain fatty acyl-CoAs | glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism | 0.931 |
AGPAT6 | GPAM | ENSP00000380184 | ENSP00000265276 | 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta); Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long- chain fatty acyl-CoAs | glycerol-3-phosphate acyltransferase, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis | 0.989 |
AGPAT6 | GPAT2 | ENSP00000380184 | ENSP00000352547 | 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta); Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long- chain fatty acyl-CoAs | glycerol-3-phosphate acyltransferase 2, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis (By similarity) | 0.766 |
AGPAT6 | GPD2 | ENSP00000380184 | ENSP00000308610 | 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta); Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long- chain fatty acyl-CoAs | glycerol-3-phosphate dehydrogenase 2 (mitochondrial) | 0.918 |
AGPAT9 | AGPAT6 | ENSP00000264409 | ENSP00000380184 | 1-acylglycerol-3-phosphate O-acyltransferase 9; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Overexpression activates the mTOR pathway | 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta); Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long- chain fatty acyl-CoAs | 0.901 |
AGPAT9 | GK | ENSP00000264409 | ENSP00000368226 | 1-acylglycerol-3-phosphate O-acyltransferase 9; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Overexpression activates the mTOR pathway | glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism | 0.925 |
AGPAT9 | GPAM | ENSP00000264409 | ENSP00000265276 | 1-acylglycerol-3-phosphate O-acyltransferase 9; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Overexpression activates the mTOR pathway | glycerol-3-phosphate acyltransferase, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis | 0.989 |
AGPAT9 | GPAT2 | ENSP00000264409 | ENSP00000352547 | 1-acylglycerol-3-phosphate O-acyltransferase 9; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Overexpression activates the mTOR pathway | glycerol-3-phosphate acyltransferase 2, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis (By similarity) | 0.791 |
AGPAT9 | GPD2 | ENSP00000264409 | ENSP00000308610 | 1-acylglycerol-3-phosphate O-acyltransferase 9; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Overexpression activates the mTOR pathway | glycerol-3-phosphate dehydrogenase 2 (mitochondrial) | 0.918 |
AKR1A1 | GK | ENSP00000312606 | ENSP00000368226 | aldo-keto reductase family 1, member A1 (aldehyde reductase); Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotic [...] | glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism | 0.910 |
AKR1B1 | GK | ENSP00000285930 | ENSP00000368226 | aldo-keto reductase family 1, member B1 (aldose reductase); Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies | glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism | 0.907 |
AQP7 | GK | ENSP00000297988 | ENSP00000368226 | aquaporin 7; Forms a channel for water and glycerol | glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism | 0.908 |
AQP7 | GPD2 | ENSP00000297988 | ENSP00000308610 | aquaporin 7; Forms a channel for water and glycerol | glycerol-3-phosphate dehydrogenase 2 (mitochondrial) | 0.747 |
GK | AGPAT6 | ENSP00000368226 | ENSP00000380184 | glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism | 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta); Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long- chain fatty acyl-CoAs | 0.931 |
GK | AGPAT9 | ENSP00000368226 | ENSP00000264409 | glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism | 1-acylglycerol-3-phosphate O-acyltransferase 9; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Overexpression activates the mTOR pathway | 0.925 |
GK | AKR1A1 | ENSP00000368226 | ENSP00000312606 | glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism | aldo-keto reductase family 1, member A1 (aldehyde reductase); Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotic [...] | 0.910 |
GK | AKR1B1 | ENSP00000368226 | ENSP00000285930 | glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism | aldo-keto reductase family 1, member B1 (aldose reductase); Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies | 0.907 |
GK | AQP7 | ENSP00000368226 | ENSP00000297988 | glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism | aquaporin 7; Forms a channel for water and glycerol | 0.908 |
GK | GPAM | ENSP00000368226 | ENSP00000265276 | glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism | glycerol-3-phosphate acyltransferase, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis | 0.920 |