node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EID3 | MAGEB6 | ENSP00000435619 | ENSP00000368320 | EP300 interacting inhibitor of differentiation 3; Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components | melanoma antigen family B, 6 | 0.698 |
EID3 | NSMCE1 | ENSP00000435619 | ENSP00000355077 | EP300 interacting inhibitor of differentiation 3; Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components | non-SMC element 1 homolog (S. cerevisiae); Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Has in vitro [...] | 0.996 |
EID3 | NSMCE4A | ENSP00000435619 | ENSP00000358019 | EP300 interacting inhibitor of differentiation 3; Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components | non-SMC element 4 homolog A (S. cerevisiae); Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Is involved [...] | 0.902 |
EID3 | SMC6 | ENSP00000435619 | ENSP00000323439 | EP300 interacting inhibitor of differentiation 3; Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components | structural maintenance of chromosomes 6; Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required fo [...] | 0.997 |
GJD4 | KRTAP5-4 | ENSP00000315070 | ENSP00000382590 | gap junction protein, delta 4, 40.1kDa; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell (By similarity) | keratin associated protein 5-4 | 0.645 |
GJD4 | MAGEB6 | ENSP00000315070 | ENSP00000368320 | gap junction protein, delta 4, 40.1kDa; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell (By similarity) | melanoma antigen family B, 6 | 0.509 |
HACL1 | MAGEB6 | ENSP00000323811 | ENSP00000368320 | 2-hydroxyacyl-CoA lyase 1; Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde | melanoma antigen family B, 6 | 0.557 |
KRTAP5-4 | GJD4 | ENSP00000382590 | ENSP00000315070 | keratin associated protein 5-4 | gap junction protein, delta 4, 40.1kDa; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell (By similarity) | 0.645 |
KRTAP5-4 | MAGEB6 | ENSP00000382590 | ENSP00000368320 | keratin associated protein 5-4 | melanoma antigen family B, 6 | 0.480 |
LRRC16B | MAGEB6 | ENSP00000340467 | ENSP00000368320 | leucine rich repeat containing 16B | melanoma antigen family B, 6 | 0.513 |
MAGEB6 | EID3 | ENSP00000368320 | ENSP00000435619 | melanoma antigen family B, 6 | EP300 interacting inhibitor of differentiation 3; Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components | 0.698 |
MAGEB6 | GJD4 | ENSP00000368320 | ENSP00000315070 | melanoma antigen family B, 6 | gap junction protein, delta 4, 40.1kDa; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell (By similarity) | 0.509 |
MAGEB6 | HACL1 | ENSP00000368320 | ENSP00000323811 | melanoma antigen family B, 6 | 2-hydroxyacyl-CoA lyase 1; Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde | 0.557 |
MAGEB6 | KRTAP5-4 | ENSP00000368320 | ENSP00000382590 | melanoma antigen family B, 6 | keratin associated protein 5-4 | 0.480 |
MAGEB6 | LRRC16B | ENSP00000368320 | ENSP00000340467 | melanoma antigen family B, 6 | leucine rich repeat containing 16B | 0.513 |
MAGEB6 | MSX1 | ENSP00000368320 | ENSP00000372170 | melanoma antigen family B, 6 | msh homeobox 1; Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity | 0.597 |
MAGEB6 | MSX2 | ENSP00000368320 | ENSP00000239243 | melanoma antigen family B, 6 | msh homeobox 2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter | 0.597 |
MAGEB6 | NSMCE1 | ENSP00000368320 | ENSP00000355077 | melanoma antigen family B, 6 | non-SMC element 1 homolog (S. cerevisiae); Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Has in vitro [...] | 0.682 |
MAGEB6 | NSMCE4A | ENSP00000368320 | ENSP00000358019 | melanoma antigen family B, 6 | non-SMC element 4 homolog A (S. cerevisiae); Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Is involved [...] | 0.698 |
MAGEB6 | SMC6 | ENSP00000368320 | ENSP00000323439 | melanoma antigen family B, 6 | structural maintenance of chromosomes 6; Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required fo [...] | 0.594 |