TPD52 protein (Homo sapiens) - STRING network view

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TPD52

tumor protein D52 (224 aa)

Predicted Functional Partners:

ANXA6

0.916

UBC

0.854

MYC

0.822

TPD52L2

0.775

PIGR

0.662

SEPHS1

0.644

SAR1A

0.644

CD59

0.607

TPD52L3

0.596

TPD52L1

0.594

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANXA6	TPD52	ENSP00000346550	ENSP00000368391	annexin A6; May associate with CD21. May regulate the release of Ca(2+) from intracellular stores	tumor protein D52	0.916
ANXA6	UBC	ENSP00000346550	ENSP00000344818	annexin A6; May associate with CD21. May regulate the release of Ca(2+) from intracellular stores	ubiquitin C	0.944
CD59	TPD52	ENSP00000340210	ENSP00000368391	CD59 molecule, complement regulatory protein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase	tumor protein D52	0.607
MYC	TPD52	ENSP00000367207	ENSP00000368391	v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes	tumor protein D52	0.822
MYC	UBC	ENSP00000367207	ENSP00000344818	v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes	ubiquitin C	0.999
PIGR	TPD52	ENSP00000348888	ENSP00000368391	polymeric immunoglobulin receptor; This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment	tumor protein D52	0.662
SAR1A	TPD52	ENSP00000362335	ENSP00000368391	SAR1 homolog A (S. cerevisiae); Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES)	tumor protein D52	0.644
SAR1A	UBC	ENSP00000362335	ENSP00000344818	SAR1 homolog A (S. cerevisiae); Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES)	ubiquitin C	0.936
SEPHS1	TPD52	ENSP00000367893	ENSP00000368391	selenophosphate synthetase 1; Synthesizes selenophosphate from selenide and ATP	tumor protein D52	0.644
SEPHS1	UBC	ENSP00000367893	ENSP00000344818	selenophosphate synthetase 1; Synthesizes selenophosphate from selenide and ATP	ubiquitin C	0.620
TPD52	ANXA6	ENSP00000368391	ENSP00000346550	tumor protein D52	annexin A6; May associate with CD21. May regulate the release of Ca(2+) from intracellular stores	0.916
TPD52	CD59	ENSP00000368391	ENSP00000340210	tumor protein D52	CD59 molecule, complement regulatory protein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase	0.607
TPD52	MYC	ENSP00000368391	ENSP00000367207	tumor protein D52	v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes	0.822
TPD52	PIGR	ENSP00000368391	ENSP00000348888	tumor protein D52	polymeric immunoglobulin receptor; This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment	0.662
TPD52	SAR1A	ENSP00000368391	ENSP00000362335	tumor protein D52	SAR1 homolog A (S. cerevisiae); Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES)	0.644
TPD52	SEPHS1	ENSP00000368391	ENSP00000367893	tumor protein D52	selenophosphate synthetase 1; Synthesizes selenophosphate from selenide and ATP	0.644
TPD52	TPD52L1	ENSP00000368391	ENSP00000434142	tumor protein D52	tumor protein D52-like 1	0.594
TPD52	TPD52L2	ENSP00000368391	ENSP00000217121	tumor protein D52	tumor protein D52-like 2	0.775
TPD52	TPD52L3	ENSP00000368391	ENSP00000341677	tumor protein D52	tumor protein D52-like 3	0.596
TPD52	UBC	ENSP00000368391	ENSP00000344818	tumor protein D52	ubiquitin C	0.854

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