SCNN1D protein (Homo sapiens) - STRING network view

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SCNN1D

sodium channel, non-voltage-gated 1, delta subunit; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception (802 aa)

Predicted Functional Partners:

UBC

0.980

SCNN1B

0.962

SCNN1G

0.960

NEDD4L

0.907

SCNN1A

0.905

RPS27A

0.905

SGK1

0.904

WNK1

0.903

WNK2

0.903

WNK4

0.903

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NEDD4L	RPS27A	ENSP00000383199	ENSP00000272317	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	ribosomal protein S27a	0.992
NEDD4L	SCNN1A	ENSP00000383199	ENSP00000353292	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	sodium channel, non-voltage-gated 1 alpha subunit; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception	0.999
NEDD4L	SCNN1B	ENSP00000383199	ENSP00000345751	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	sodium channel, non-voltage-gated 1, beta subunit; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception	0.999
NEDD4L	SCNN1D	ENSP00000383199	ENSP00000368411	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	sodium channel, non-voltage-gated 1, delta subunit; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception	0.907
NEDD4L	SCNN1G	ENSP00000383199	ENSP00000300061	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	sodium channel, non-voltage-gated 1, gamma subunit	0.999
NEDD4L	SGK1	ENSP00000383199	ENSP00000356832	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	serum/glucocorticoid regulated kinase 1	0.999
NEDD4L	UBC	ENSP00000383199	ENSP00000344818	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	ubiquitin C	0.999
NEDD4L	WNK1	ENSP00000383199	ENSP00000313059	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	WNK lysine deficient protein kinase 1	0.900
NEDD4L	WNK2	ENSP00000383199	ENSP00000297954	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	WNK lysine deficient protein kinase 2; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulati [...]	0.525
NEDD4L	WNK4	ENSP00000383199	ENSP00000246914	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	WNK lysine deficient protein kinase 4; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-i [...]	0.864
RPS27A	NEDD4L	ENSP00000272317	ENSP00000383199	ribosomal protein S27a	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	0.992
RPS27A	SCNN1A	ENSP00000272317	ENSP00000353292	ribosomal protein S27a	sodium channel, non-voltage-gated 1 alpha subunit; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception	0.905
RPS27A	SCNN1B	ENSP00000272317	ENSP00000345751	ribosomal protein S27a	sodium channel, non-voltage-gated 1, beta subunit; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception	0.911
RPS27A	SCNN1D	ENSP00000272317	ENSP00000368411	ribosomal protein S27a	sodium channel, non-voltage-gated 1, delta subunit; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception	0.905
RPS27A	SCNN1G	ENSP00000272317	ENSP00000300061	ribosomal protein S27a	sodium channel, non-voltage-gated 1, gamma subunit	0.911
RPS27A	SGK1	ENSP00000272317	ENSP00000356832	ribosomal protein S27a	serum/glucocorticoid regulated kinase 1	0.913
RPS27A	UBC	ENSP00000272317	ENSP00000344818	ribosomal protein S27a	ubiquitin C	0.999
RPS27A	WNK1	ENSP00000272317	ENSP00000313059	ribosomal protein S27a	WNK lysine deficient protein kinase 1	0.901
RPS27A	WNK2	ENSP00000272317	ENSP00000297954	ribosomal protein S27a	WNK lysine deficient protein kinase 2; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulati [...]	0.900
RPS27A	WNK4	ENSP00000272317	ENSP00000246914	ribosomal protein S27a	WNK lysine deficient protein kinase 4; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-i [...]	0.900

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