| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C15orf40 | SERP2 | ENSP00000403987 | ENSP00000368477 | chromosome 15 open reading frame 40 | stress-associated endoplasmic reticulum protein family member 2; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation (Potential) | 0.563 |
| CKB | SERP2 | ENSP00000299198 | ENSP00000368477 | creatine kinase, brain; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | stress-associated endoplasmic reticulum protein family member 2; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation (Potential) | 0.530 |
| PLAU | SERP2 | ENSP00000361850 | ENSP00000368477 | plasminogen activator, urokinase; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin | stress-associated endoplasmic reticulum protein family member 2; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation (Potential) | 0.786 |
| PLAU | SERPINE2 | ENSP00000361850 | ENSP00000415786 | plasminogen activator, urokinase; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin | 0.942 |
| SEC11A | SEC11C | ENSP00000268220 | ENSP00000468633 | SEC11 homolog A (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) | SEC11 homolog C (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) | 0.902 |
| SEC11A | SEC61B | ENSP00000268220 | ENSP00000223641 | SEC11 homolog A (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) | Sec61 beta subunit; Necessary for protein translocation in the endoplasmic reticulum | 0.997 |
| SEC11A | SERP2 | ENSP00000268220 | ENSP00000368477 | SEC11 homolog A (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) | stress-associated endoplasmic reticulum protein family member 2; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation (Potential) | 0.736 |
| SEC11A | SPCS1 | ENSP00000268220 | ENSP00000233025 | SEC11 homolog A (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) | signal peptidase complex subunit 1 homolog (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) | 0.998 |
| SEC11A | TMED10 | ENSP00000268220 | ENSP00000303145 | SEC11 homolog A (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) | transmembrane emp24-like trafficking protein 10 (yeast); Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act togther with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipi [...] | 0.981 |
| SEC11A | TMED6 | ENSP00000268220 | ENSP00000288025 | SEC11 homolog A (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) | transmembrane emp24 protein transport domain containing 6 | 0.531 |
| SEC11C | SEC11A | ENSP00000468633 | ENSP00000268220 | SEC11 homolog C (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) | SEC11 homolog A (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) | 0.902 |
| SEC11C | SEC61B | ENSP00000468633 | ENSP00000223641 | SEC11 homolog C (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) | Sec61 beta subunit; Necessary for protein translocation in the endoplasmic reticulum | 0.997 |
| SEC11C | SERP2 | ENSP00000468633 | ENSP00000368477 | SEC11 homolog C (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) | stress-associated endoplasmic reticulum protein family member 2; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation (Potential) | 0.780 |
| SEC11C | SPCS1 | ENSP00000468633 | ENSP00000233025 | SEC11 homolog C (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) | signal peptidase complex subunit 1 homolog (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) | 0.998 |
| SEC11C | TMED10 | ENSP00000468633 | ENSP00000303145 | SEC11 homolog C (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) | transmembrane emp24-like trafficking protein 10 (yeast); Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act togther with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipi [...] | 0.978 |
| SEC11C | TMED6 | ENSP00000468633 | ENSP00000288025 | SEC11 homolog C (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) | transmembrane emp24 protein transport domain containing 6 | 0.531 |
| SEC61B | SEC11A | ENSP00000223641 | ENSP00000268220 | Sec61 beta subunit; Necessary for protein translocation in the endoplasmic reticulum | SEC11 homolog A (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) | 0.997 |
| SEC61B | SEC11C | ENSP00000223641 | ENSP00000468633 | Sec61 beta subunit; Necessary for protein translocation in the endoplasmic reticulum | SEC11 homolog C (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) | 0.997 |
| SEC61B | SERP2 | ENSP00000223641 | ENSP00000368477 | Sec61 beta subunit; Necessary for protein translocation in the endoplasmic reticulum | stress-associated endoplasmic reticulum protein family member 2; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation (Potential) | 0.718 |
| SEC61B | SPCS1 | ENSP00000223641 | ENSP00000233025 | Sec61 beta subunit; Necessary for protein translocation in the endoplasmic reticulum | signal peptidase complex subunit 1 homolog (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) | 0.967 |
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