node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LGR4 | PITX2 | ENSP00000368516 | ENSP00000304169 | leucine-rich repeat containing G protein-coupled receptor 4; Orphan receptor | paired-like homeodomain 2; Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo (By similarity) | 0.909 |
LGR4 | RPS27A | ENSP00000368516 | ENSP00000272317 | leucine-rich repeat containing G protein-coupled receptor 4; Orphan receptor | ribosomal protein S27a | 0.907 |
LGR4 | RSPO1 | ENSP00000368516 | ENSP00000348944 | leucine-rich repeat containing G protein-coupled receptor 4; Orphan receptor | R-spondin 1; Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination | 0.999 |
LGR4 | RSPO2 | ENSP00000368516 | ENSP00000276659 | leucine-rich repeat containing G protein-coupled receptor 4; Orphan receptor | R-spondin 2; Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors (By similarity) | 0.976 |
LGR4 | RSPO3 | ENSP00000368516 | ENSP00000349131 | leucine-rich repeat containing G protein-coupled receptor 4; Orphan receptor | R-spondin 3; Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (By similarity) | 0.980 |
LGR4 | RSPO4 | ENSP00000368516 | ENSP00000217260 | leucine-rich repeat containing G protein-coupled receptor 4; Orphan receptor | R-spondin 4; Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (By similarity) | 0.978 |
LGR4 | UBA52 | ENSP00000368516 | ENSP00000388107 | leucine-rich repeat containing G protein-coupled receptor 4; Orphan receptor | ubiquitin A-52 residue ribosomal protein fusion product 1 | 0.912 |
LGR4 | UBB | ENSP00000368516 | ENSP00000304697 | leucine-rich repeat containing G protein-coupled receptor 4; Orphan receptor | ubiquitin B | 0.917 |
LGR4 | UBC | ENSP00000368516 | ENSP00000344818 | leucine-rich repeat containing G protein-coupled receptor 4; Orphan receptor | ubiquitin C | 0.955 |
LGR4 | ZNRF3 | ENSP00000368516 | ENSP00000443824 | leucine-rich repeat containing G protein-coupled receptor 4; Orphan receptor | zinc and ring finger 3; E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non- canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone | 0.995 |
PITX2 | LGR4 | ENSP00000304169 | ENSP00000368516 | paired-like homeodomain 2; Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo (By similarity) | leucine-rich repeat containing G protein-coupled receptor 4; Orphan receptor | 0.909 |
RPS27A | LGR4 | ENSP00000272317 | ENSP00000368516 | ribosomal protein S27a | leucine-rich repeat containing G protein-coupled receptor 4; Orphan receptor | 0.907 |
RPS27A | RSPO1 | ENSP00000272317 | ENSP00000348944 | ribosomal protein S27a | R-spondin 1; Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination | 0.904 |
RPS27A | RSPO2 | ENSP00000272317 | ENSP00000276659 | ribosomal protein S27a | R-spondin 2; Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors (By similarity) | 0.900 |
RPS27A | RSPO3 | ENSP00000272317 | ENSP00000349131 | ribosomal protein S27a | R-spondin 3; Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (By similarity) | 0.904 |
RPS27A | RSPO4 | ENSP00000272317 | ENSP00000217260 | ribosomal protein S27a | R-spondin 4; Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (By similarity) | 0.904 |
RPS27A | UBA52 | ENSP00000272317 | ENSP00000388107 | ribosomal protein S27a | ubiquitin A-52 residue ribosomal protein fusion product 1 | 0.978 |
RPS27A | UBB | ENSP00000272317 | ENSP00000304697 | ribosomal protein S27a | ubiquitin B | 0.972 |
RPS27A | UBC | ENSP00000272317 | ENSP00000344818 | ribosomal protein S27a | ubiquitin C | 0.999 |
RPS27A | ZNRF3 | ENSP00000272317 | ENSP00000443824 | ribosomal protein S27a | zinc and ring finger 3; E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non- canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone | 0.909 |