node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IL2 | IL2RA | ENSP00000226730 | ENSP00000369293 | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | interleukin 2 receptor, alpha; Receptor for interleukin-2 | 0.999 |
IL2 | IL2RB | ENSP00000226730 | ENSP00000216223 | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | interleukin 2 receptor, beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2 | 0.999 |
IL2 | IL2RG | ENSP00000226730 | ENSP00000363318 | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | interleukin 2 receptor, gamma; Common subunit for the receptors for a variety of interleukins | 0.999 |
IL2 | IL4 | ENSP00000226730 | ENSP00000231449 | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | interleukin 4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes | 0.995 |
IL2 | TNFRSF4 | ENSP00000226730 | ENSP00000368538 | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | tumor necrosis factor receptor superfamily, member 4; Receptor for TNFSF4/OX40L/GP34 | 0.930 |
IL2 | TNFRSF9 | ENSP00000226730 | ENSP00000366729 | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | tumor necrosis factor receptor superfamily, member 9; Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation | 0.933 |
IL2 | TSLP | ENSP00000226730 | ENSP00000339804 | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | thymic stromal lymphopoietin; Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells | 0.855 |
IL2RA | IL2 | ENSP00000369293 | ENSP00000226730 | interleukin 2 receptor, alpha; Receptor for interleukin-2 | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | 0.999 |
IL2RA | IL2RB | ENSP00000369293 | ENSP00000216223 | interleukin 2 receptor, alpha; Receptor for interleukin-2 | interleukin 2 receptor, beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2 | 0.999 |
IL2RA | IL2RG | ENSP00000369293 | ENSP00000363318 | interleukin 2 receptor, alpha; Receptor for interleukin-2 | interleukin 2 receptor, gamma; Common subunit for the receptors for a variety of interleukins | 0.996 |
IL2RA | IL4 | ENSP00000369293 | ENSP00000231449 | interleukin 2 receptor, alpha; Receptor for interleukin-2 | interleukin 4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes | 0.850 |
IL2RA | TNFRSF4 | ENSP00000369293 | ENSP00000368538 | interleukin 2 receptor, alpha; Receptor for interleukin-2 | tumor necrosis factor receptor superfamily, member 4; Receptor for TNFSF4/OX40L/GP34 | 0.932 |
IL2RA | TNFRSF9 | ENSP00000369293 | ENSP00000366729 | interleukin 2 receptor, alpha; Receptor for interleukin-2 | tumor necrosis factor receptor superfamily, member 9; Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation | 0.912 |
IL2RA | TSLP | ENSP00000369293 | ENSP00000339804 | interleukin 2 receptor, alpha; Receptor for interleukin-2 | thymic stromal lymphopoietin; Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells | 0.813 |
IL2RB | IL2 | ENSP00000216223 | ENSP00000226730 | interleukin 2 receptor, beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2 | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | 0.999 |
IL2RB | IL2RA | ENSP00000216223 | ENSP00000369293 | interleukin 2 receptor, beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2 | interleukin 2 receptor, alpha; Receptor for interleukin-2 | 0.999 |
IL2RB | IL2RG | ENSP00000216223 | ENSP00000363318 | interleukin 2 receptor, beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2 | interleukin 2 receptor, gamma; Common subunit for the receptors for a variety of interleukins | 0.999 |
IL2RB | IL4 | ENSP00000216223 | ENSP00000231449 | interleukin 2 receptor, beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2 | interleukin 4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes | 0.873 |
IL2RB | TNFRSF4 | ENSP00000216223 | ENSP00000368538 | interleukin 2 receptor, beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2 | tumor necrosis factor receptor superfamily, member 4; Receptor for TNFSF4/OX40L/GP34 | 0.918 |
IL2RB | TNFRSF9 | ENSP00000216223 | ENSP00000366729 | interleukin 2 receptor, beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2 | tumor necrosis factor receptor superfamily, member 9; Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation | 0.915 |