FEZ2 protein (Homo sapiens) - STRING network view

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FEZ2

fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity) (380 aa)

Predicted Functional Partners:

SCOC

0.927

CRIM1

0.860

LZTS1

0.750

KIF5B

0.749

KIF5A

0.747

KIF5C

0.747

NEK1

0.693

ATF5

0.686

SAP30L

0.655

C16orf59

0.654

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATF5	FEZ2	ENSP00000396954	ENSP00000368547	activating transcription factor 5; Transcriptional activator which binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4	fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity)	0.686
ATF5	LZTS1	ENSP00000396954	ENSP00000265801	activating transcription factor 5; Transcriptional activator which binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4	leucine zipper, putative tumor suppressor 1; Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor	0.590
C16orf59	FEZ2	ENSP00000355022	ENSP00000368547	chromosome 16 open reading frame 59	fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity)	0.654
C16orf59	SAP30L	ENSP00000355022	ENSP00000297109	chromosome 16 open reading frame 59	SAP30-like; Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus	0.509
C16orf59	SCOC	ENSP00000355022	ENSP00000377751	chromosome 16 open reading frame 59	short coiled-coil protein	0.473
CRIM1	FEZ2	ENSP00000280527	ENSP00000368547	cysteine rich transmembrane BMP regulator 1 (chordin-like); May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface	fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity)	0.860
FEZ2	ATF5	ENSP00000368547	ENSP00000396954	fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity)	activating transcription factor 5; Transcriptional activator which binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4	0.686
FEZ2	C16orf59	ENSP00000368547	ENSP00000355022	fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity)	chromosome 16 open reading frame 59	0.654
FEZ2	CRIM1	ENSP00000368547	ENSP00000280527	fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity)	cysteine rich transmembrane BMP regulator 1 (chordin-like); May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface	0.860
FEZ2	KIF5A	ENSP00000368547	ENSP00000408979	fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity)	kinesin family member 5A; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL) (By similarity)	0.747
FEZ2	KIF5B	ENSP00000368547	ENSP00000307078	fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity)	kinesin family member 5B; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (By similarity)	0.749
FEZ2	KIF5C	ENSP00000368547	ENSP00000393379	fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity)	kinesin family member 5C	0.747
FEZ2	LZTS1	ENSP00000368547	ENSP00000265801	fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity)	leucine zipper, putative tumor suppressor 1; Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor	0.750
FEZ2	NEK1	ENSP00000368547	ENSP00000424757	fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity)	NIMA-related kinase 1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated in the control of meiosis (By similarity). Involved in cilium assembly	0.693
FEZ2	SAP30L	ENSP00000368547	ENSP00000297109	fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity)	SAP30-like; Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus	0.655
FEZ2	SCOC	ENSP00000368547	ENSP00000377751	fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity)	short coiled-coil protein	0.927
KIF5A	FEZ2	ENSP00000408979	ENSP00000368547	kinesin family member 5A; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL) (By similarity)	fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity)	0.747
KIF5A	KIF5B	ENSP00000408979	ENSP00000307078	kinesin family member 5A; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL) (By similarity)	kinesin family member 5B; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (By similarity)	0.630
KIF5B	FEZ2	ENSP00000307078	ENSP00000368547	kinesin family member 5B; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (By similarity)	fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity)	0.749
KIF5B	KIF5A	ENSP00000307078	ENSP00000408979	kinesin family member 5B; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (By similarity)	kinesin family member 5A; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL) (By similarity)	0.630

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