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STRINGSTRING
EEF1D EEF1D RPL31 RPL31 EEF1B2 EEF1B2 HSPA14 HSPA14 LTN1 LTN1 DNAJC2 DNAJC2 UBC UBC HDLBP HDLBP DNAJC21 DNAJC21 TTC37 TTC37 HSPA8 HSPA8
"DNAJC2" - DnaJ in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
DNAJC2DnaJ (Hsp40) homolog, subfamily C, member 2; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone- component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state- specifically recruit [...] (621 aa)    
Predicted Functional Partners:
HSPA14
heat shock 70kDa protein 14; Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity (509 aa)
      score_image score_image   score_image   0.959
HDLBP
high density lipoprotein binding protein; Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol (1268 aa)
      score_image score_image   score_image   0.943
RPL31
ribosomal protein L31 (128 aa)
      score_image score_image   score_image   0.901
TTC37
tetratricopeptide repeat domain 37; Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) (1564 aa)
        score_image       0.890
EEF1B2
eukaryotic translation elongation factor 1 beta 2; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP (225 aa)
      score_image score_image   score_image   0.877
DNAJC21
DnaJ (Hsp40) homolog, subfamily C, member 21; May act as a co-chaperone for HSP70 (576 aa)
      score_image score_image   score_image score_image 0.810
LTN1
listerin E3 ubiquitin protein ligase 1 (1812 aa)
        score_image   score_image   0.810
HSPA8
heat shock 70kDa protein 8; Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (646 aa)
      score_image score_image   score_image   0.806
EEF1D
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein); Isoform 1- EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1- alpha for another round of transfer of aminoacyl-tRNAs to the ribosome (647 aa)
      score_image score_image   score_image   0.755
UBC
ubiquitin C (685 aa)
      score_image score_image       0.737
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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