node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAT1 | ACOT9 | ENSP00000265838 | ENSP00000368605 | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | acyl-CoA thioesterase 9; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs | 0.573 |
ACAT1 | UBC | ENSP00000265838 | ENSP00000344818 | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | ubiquitin C | 0.727 |
ACOT8 | ACOT9 | ENSP00000217455 | ENSP00000368605 | acyl-CoA thioesterase 8; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA- amino acid N- acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (By similarity). May be involved in the metabolic regulation of peroxi [...] | acyl-CoA thioesterase 9; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs | 0.453 |
ACOT8 | UBC | ENSP00000217455 | ENSP00000344818 | acyl-CoA thioesterase 8; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA- amino acid N- acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (By similarity). May be involved in the metabolic regulation of peroxi [...] | ubiquitin C | 0.821 |
ACOT9 | ACAT1 | ENSP00000368605 | ENSP00000265838 | acyl-CoA thioesterase 9; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | 0.573 |
ACOT9 | ACOT8 | ENSP00000368605 | ENSP00000217455 | acyl-CoA thioesterase 9; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs | acyl-CoA thioesterase 8; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA- amino acid N- acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (By similarity). May be involved in the metabolic regulation of peroxi [...] | 0.453 |
ACOT9 | APOO | ENSP00000368605 | ENSP00000368528 | acyl-CoA thioesterase 9; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs | apolipoprotein O; Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation | 0.636 |
ACOT9 | CERS1 | ENSP00000368605 | ENSP00000402697 | acyl-CoA thioesterase 9; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs | ceramide synthase 1; May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner (By similarity) | 0.514 |
ACOT9 | GRSF1 | ENSP00000368605 | ENSP00000254799 | acyl-CoA thioesterase 9; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs | G-rich RNA sequence binding factor 1; Binds RNAs containing the 14 base G-rich element | 0.481 |
ACOT9 | METAP1 | ENSP00000368605 | ENSP00000296411 | acyl-CoA thioesterase 9; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs | methionyl aminopeptidase 1; Removes the N-terminal methionine from nascent proteins. Required for normal progression through the cell cycle | 0.463 |
ACOT9 | MINOS1 | ENSP00000368605 | ENSP00000325562 | acyl-CoA thioesterase 9; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs | mitochondrial inner membrane organizing system 1; May play a role in mitochondrial architecture (By similarity) | 0.512 |
ACOT9 | MYO16 | ENSP00000368605 | ENSP00000349145 | acyl-CoA thioesterase 9; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs | myosin XVI | 0.570 |
ACOT9 | NUDCD3 | ENSP00000368605 | ENSP00000347626 | acyl-CoA thioesterase 9; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs | NudC domain containing 3 | 0.478 |
ACOT9 | UBC | ENSP00000368605 | ENSP00000344818 | acyl-CoA thioesterase 9; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs | ubiquitin C | 0.800 |
APOO | ACOT9 | ENSP00000368528 | ENSP00000368605 | apolipoprotein O; Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation | acyl-CoA thioesterase 9; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs | 0.636 |
CERS1 | ACOT9 | ENSP00000402697 | ENSP00000368605 | ceramide synthase 1; May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner (By similarity) | acyl-CoA thioesterase 9; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs | 0.514 |
CERS1 | UBC | ENSP00000402697 | ENSP00000344818 | ceramide synthase 1; May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner (By similarity) | ubiquitin C | 0.708 |
GRSF1 | ACOT9 | ENSP00000254799 | ENSP00000368605 | G-rich RNA sequence binding factor 1; Binds RNAs containing the 14 base G-rich element | acyl-CoA thioesterase 9; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs | 0.481 |
GRSF1 | UBC | ENSP00000254799 | ENSP00000344818 | G-rich RNA sequence binding factor 1; Binds RNAs containing the 14 base G-rich element | ubiquitin C | 0.878 |
METAP1 | ACOT9 | ENSP00000296411 | ENSP00000368605 | methionyl aminopeptidase 1; Removes the N-terminal methionine from nascent proteins. Required for normal progression through the cell cycle | acyl-CoA thioesterase 9; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs | 0.463 |