VWA8 protein (Homo sapiens) - STRING network view

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VWA8

von Willebrand factor A domain containing 8 (1905 aa)

Predicted Functional Partners:

KEAP1

0.740

VKORC1L1

0.471

CCDC127

0.459

SPEG

0.436

ARFGAP3

0.416

ARFGAP1

0.411

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARFGAP1	ARFGAP3	ENSP00000314615	ENSP00000263245	ADP-ribosylation factor GTPase activating protein 1	ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes	0.885
ARFGAP1	VWA8	ENSP00000314615	ENSP00000368612	ADP-ribosylation factor GTPase activating protein 1	von Willebrand factor A domain containing 8	0.411
ARFGAP3	ARFGAP1	ENSP00000263245	ENSP00000314615	ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes	ADP-ribosylation factor GTPase activating protein 1	0.885
ARFGAP3	VWA8	ENSP00000263245	ENSP00000368612	ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes	von Willebrand factor A domain containing 8	0.416
CCDC127	VWA8	ENSP00000296824	ENSP00000368612	coiled-coil domain containing 127	von Willebrand factor A domain containing 8	0.459
KEAP1	VWA8	ENSP00000171111	ENSP00000368612	kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome	von Willebrand factor A domain containing 8	0.740
SPEG	VWA8	ENSP00000311684	ENSP00000368612	SPEG complex locus	von Willebrand factor A domain containing 8	0.436
VKORC1L1	VWA8	ENSP00000353998	ENSP00000368612	vitamin K epoxide reductase complex, subunit 1-like 1	von Willebrand factor A domain containing 8	0.471
VWA8	ARFGAP1	ENSP00000368612	ENSP00000314615	von Willebrand factor A domain containing 8	ADP-ribosylation factor GTPase activating protein 1	0.411
VWA8	ARFGAP3	ENSP00000368612	ENSP00000263245	von Willebrand factor A domain containing 8	ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes	0.416
VWA8	CCDC127	ENSP00000368612	ENSP00000296824	von Willebrand factor A domain containing 8	coiled-coil domain containing 127	0.459
VWA8	KEAP1	ENSP00000368612	ENSP00000171111	von Willebrand factor A domain containing 8	kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome	0.740
VWA8	SPEG	ENSP00000368612	ENSP00000311684	von Willebrand factor A domain containing 8	SPEG complex locus	0.436
VWA8	VKORC1L1	ENSP00000368612	ENSP00000353998	von Willebrand factor A domain containing 8	vitamin K epoxide reductase complex, subunit 1-like 1	0.471

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