| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BMP2 | FGF23 | ENSP00000368104 | ENSP00000237837 | bone morphogenetic protein 2; Induces cartilage and bone formation | fibroblast growth factor 23; Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization | 0.504 |
| BMP2 | IGF1 | ENSP00000368104 | ENSP00000302665 | bone morphogenetic protein 2; Induces cartilage and bone formation | insulin-like growth factor 1 (somatomedin C); The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake | 0.581 |
| BMP2 | MEPE | ENSP00000368104 | ENSP00000354341 | bone morphogenetic protein 2; Induces cartilage and bone formation | matrix extracellular phosphoglycoprotein; Promotes renal phosphate excretion and modulates mineralization | 0.860 |
| BMP2 | PHEX | ENSP00000368104 | ENSP00000368682 | bone morphogenetic protein 2; Induces cartilage and bone formation | phosphate regulating endopeptidase homolog, X-linked; Probably involved in bone and dentin mineralization and renal phosphate reabsorption | 0.829 |
| BMP2 | PTH | ENSP00000368104 | ENSP00000282091 | bone morphogenetic protein 2; Induces cartilage and bone formation | parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells | 0.937 |
| C1QBP | PHEX | ENSP00000225698 | ENSP00000368682 | complement component 1, q subcomponent binding protein; Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular "heads" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokera [...] | phosphate regulating endopeptidase homolog, X-linked; Probably involved in bone and dentin mineralization and renal phosphate reabsorption | 0.803 |
| CANX | PHEX | ENSP00000247461 | ENSP00000368682 | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | phosphate regulating endopeptidase homolog, X-linked; Probably involved in bone and dentin mineralization and renal phosphate reabsorption | 0.813 |
| FGF23 | BMP2 | ENSP00000237837 | ENSP00000368104 | fibroblast growth factor 23; Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization | bone morphogenetic protein 2; Induces cartilage and bone formation | 0.504 |
| FGF23 | MEPE | ENSP00000237837 | ENSP00000354341 | fibroblast growth factor 23; Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization | matrix extracellular phosphoglycoprotein; Promotes renal phosphate excretion and modulates mineralization | 0.824 |
| FGF23 | PHEX | ENSP00000237837 | ENSP00000368682 | fibroblast growth factor 23; Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization | phosphate regulating endopeptidase homolog, X-linked; Probably involved in bone and dentin mineralization and renal phosphate reabsorption | 0.988 |
| FGF23 | PTH | ENSP00000237837 | ENSP00000282091 | fibroblast growth factor 23; Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization | parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells | 0.980 |
| IGF1 | BMP2 | ENSP00000302665 | ENSP00000368104 | insulin-like growth factor 1 (somatomedin C); The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake | bone morphogenetic protein 2; Induces cartilage and bone formation | 0.581 |
| IGF1 | PHEX | ENSP00000302665 | ENSP00000368682 | insulin-like growth factor 1 (somatomedin C); The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake | phosphate regulating endopeptidase homolog, X-linked; Probably involved in bone and dentin mineralization and renal phosphate reabsorption | 0.842 |
| IGF1 | PTH | ENSP00000302665 | ENSP00000282091 | insulin-like growth factor 1 (somatomedin C); The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake | parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells | 0.730 |
| IGF1 | TNF | ENSP00000302665 | ENSP00000398698 | insulin-like growth factor 1 (somatomedin C); The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake | tumor necrosis factor | 0.562 |
| MEPE | BMP2 | ENSP00000354341 | ENSP00000368104 | matrix extracellular phosphoglycoprotein; Promotes renal phosphate excretion and modulates mineralization | bone morphogenetic protein 2; Induces cartilage and bone formation | 0.860 |
| MEPE | FGF23 | ENSP00000354341 | ENSP00000237837 | matrix extracellular phosphoglycoprotein; Promotes renal phosphate excretion and modulates mineralization | fibroblast growth factor 23; Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization | 0.824 |
| MEPE | PHEX | ENSP00000354341 | ENSP00000368682 | matrix extracellular phosphoglycoprotein; Promotes renal phosphate excretion and modulates mineralization | phosphate regulating endopeptidase homolog, X-linked; Probably involved in bone and dentin mineralization and renal phosphate reabsorption | 0.960 |
| MEPE | PTH | ENSP00000354341 | ENSP00000282091 | matrix extracellular phosphoglycoprotein; Promotes renal phosphate excretion and modulates mineralization | parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells | 0.634 |
| PEX12 | PEX5 | ENSP00000225873 | ENSP00000407401 | peroxisomal biogenesis factor 12; Required for protein import into peroxisomes | peroxisomal biogenesis factor 5; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import | 0.999 |
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