node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSG00000259741 | RASSF2 | ENSP00000452959 | ENSP00000368684 | zinc finger MYND domain-containing protein 11 isoform g | Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation | 0.631 |
HRAS | KRAS | ENSP00000309845 | ENSP00000256078 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.901 |
HRAS | RASSF2 | ENSP00000309845 | ENSP00000368684 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation | 0.940 |
KRAS | HRAS | ENSP00000256078 | ENSP00000309845 | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.901 |
KRAS | RASSF2 | ENSP00000256078 | ENSP00000368684 | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation | 0.944 |
MST1 | RASSF2 | ENSP00000414287 | ENSP00000368684 | macrophage stimulating 1 (hepatocyte growth factor-like) | Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation | 0.999 |
MST1 | STK3 | ENSP00000414287 | ENSP00000390500 | macrophage stimulating 1 (hepatocyte growth factor-like) | serine/threonine kinase 3; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, wh [...] | 0.986 |
MST1 | STK4 | ENSP00000414287 | ENSP00000361892 | macrophage stimulating 1 (hepatocyte growth factor-like) | serine/threonine kinase 4; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, wh [...] | 0.999 |
MST4 | RASSF2 | ENSP00000377867 | ENSP00000368684 | Serine/threonine-protein kinase MST4 ; Mediator of cell growth. Modulates apoptosis | Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation | 0.680 |
MST4 | STK24 | ENSP00000377867 | ENSP00000365730 | Serine/threonine-protein kinase MST4 ; Mediator of cell growth. Modulates apoptosis | serine/threonine kinase 24; Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on ’Thr-442’ and stimulates [...] | 0.999 |
MST4 | STK25 | ENSP00000377867 | ENSP00000325748 | Serine/threonine-protein kinase MST4 ; Mediator of cell growth. Modulates apoptosis | serine/threonine kinase 25; Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration | 0.999 |
PAWR | RASSF2 | ENSP00000328088 | ENSP00000368684 | PRKC, apoptosis, WT1, regulator; Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by [...] | Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation | 0.817 |
RASSF2 | ENSG00000259741 | ENSP00000368684 | ENSP00000452959 | Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation | zinc finger MYND domain-containing protein 11 isoform g | 0.631 |
RASSF2 | HRAS | ENSP00000368684 | ENSP00000309845 | Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.940 |
RASSF2 | KRAS | ENSP00000368684 | ENSP00000256078 | Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.944 |
RASSF2 | MST1 | ENSP00000368684 | ENSP00000414287 | Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation | macrophage stimulating 1 (hepatocyte growth factor-like) | 0.999 |
RASSF2 | MST4 | ENSP00000368684 | ENSP00000377867 | Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation | Serine/threonine-protein kinase MST4 ; Mediator of cell growth. Modulates apoptosis | 0.680 |
RASSF2 | PAWR | ENSP00000368684 | ENSP00000328088 | Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation | PRKC, apoptosis, WT1, regulator; Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by [...] | 0.817 |
RASSF2 | STK24 | ENSP00000368684 | ENSP00000365730 | Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation | serine/threonine kinase 24; Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on ’Thr-442’ and stimulates [...] | 0.663 |
RASSF2 | STK25 | ENSP00000368684 | ENSP00000325748 | Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation | serine/threonine kinase 25; Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration | 0.655 |