LYRM7 protein (Homo sapiens) - STRING network view

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LYRM7

LYR motif containing 7; Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane (104 aa)

Predicted Functional Partners:

UQCRFS1

0.733

SDHAF1

0.635

ENSG00000267059

0.563

PXDC1

0.514

UQCRQ

0.502

UBC

0.483

TTC19

0.471

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSG00000267059	LYRM7	ENSP00000262946	ENSP00000368688	Cytochrome b-c1 complex subunit 10 ; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain	LYR motif containing 7; Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane	0.563
ENSG00000267059	TTC19	ENSP00000262946	ENSP00000261647	Cytochrome b-c1 complex subunit 10 ; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain	tetratricopeptide repeat domain 19; Mitochondrial protein required for formation of the mitochondrial complex III (PubMed-21278747). May also be required for the abcission step in cytokinesis, possibly regulating the ESCRT-III complex via its interaction with CHMP4B (PubMed-20208530). However, the involvement in cytokinesis requires additional experimental evidence	0.696
ENSG00000267059	UQCRFS1	ENSP00000262946	ENSP00000306397	Cytochrome b-c1 complex subunit 10 ; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	0.642
ENSG00000267059	UQCRQ	ENSP00000262946	ENSP00000367934	Cytochrome b-c1 complex subunit 10 ; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain	ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone	0.930
LYRM7	ENSG00000267059	ENSP00000368688	ENSP00000262946	LYR motif containing 7; Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane	Cytochrome b-c1 complex subunit 10 ; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain	0.563
LYRM7	PXDC1	ENSP00000368688	ENSP00000369636	LYR motif containing 7; Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane	PX domain containing 1	0.514
LYRM7	SDHAF1	ENSP00000368688	ENSP00000368165	LYR motif containing 7; Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane	succinate dehydrogenase complex assembly factor 1; Plays an essential role in succinate dehydrogenase complex (SDH) assembly, a complex involved in complex II of the mitochondrial electron transport chain. Probably acts by participating in mitochondrial biosynthesis of iron-sulfur centers for complex II (Probable)	0.635
LYRM7	TTC19	ENSP00000368688	ENSP00000261647	LYR motif containing 7; Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane	tetratricopeptide repeat domain 19; Mitochondrial protein required for formation of the mitochondrial complex III (PubMed-21278747). May also be required for the abcission step in cytokinesis, possibly regulating the ESCRT-III complex via its interaction with CHMP4B (PubMed-20208530). However, the involvement in cytokinesis requires additional experimental evidence	0.471
LYRM7	UBC	ENSP00000368688	ENSP00000344818	LYR motif containing 7; Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane	ubiquitin C	0.483
LYRM7	UQCRFS1	ENSP00000368688	ENSP00000306397	LYR motif containing 7; Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	0.733
LYRM7	UQCRQ	ENSP00000368688	ENSP00000367934	LYR motif containing 7; Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane	ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone	0.502
PXDC1	LYRM7	ENSP00000369636	ENSP00000368688	PX domain containing 1	LYR motif containing 7; Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane	0.514
SDHAF1	LYRM7	ENSP00000368165	ENSP00000368688	succinate dehydrogenase complex assembly factor 1; Plays an essential role in succinate dehydrogenase complex (SDH) assembly, a complex involved in complex II of the mitochondrial electron transport chain. Probably acts by participating in mitochondrial biosynthesis of iron-sulfur centers for complex II (Probable)	LYR motif containing 7; Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane	0.635
SDHAF1	TTC19	ENSP00000368165	ENSP00000261647	succinate dehydrogenase complex assembly factor 1; Plays an essential role in succinate dehydrogenase complex (SDH) assembly, a complex involved in complex II of the mitochondrial electron transport chain. Probably acts by participating in mitochondrial biosynthesis of iron-sulfur centers for complex II (Probable)	tetratricopeptide repeat domain 19; Mitochondrial protein required for formation of the mitochondrial complex III (PubMed-21278747). May also be required for the abcission step in cytokinesis, possibly regulating the ESCRT-III complex via its interaction with CHMP4B (PubMed-20208530). However, the involvement in cytokinesis requires additional experimental evidence	0.703
SDHAF1	UQCRQ	ENSP00000368165	ENSP00000367934	succinate dehydrogenase complex assembly factor 1; Plays an essential role in succinate dehydrogenase complex (SDH) assembly, a complex involved in complex II of the mitochondrial electron transport chain. Probably acts by participating in mitochondrial biosynthesis of iron-sulfur centers for complex II (Probable)	ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone	0.450
TTC19	ENSG00000267059	ENSP00000261647	ENSP00000262946	tetratricopeptide repeat domain 19; Mitochondrial protein required for formation of the mitochondrial complex III (PubMed-21278747). May also be required for the abcission step in cytokinesis, possibly regulating the ESCRT-III complex via its interaction with CHMP4B (PubMed-20208530). However, the involvement in cytokinesis requires additional experimental evidence	Cytochrome b-c1 complex subunit 10 ; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain	0.696
TTC19	LYRM7	ENSP00000261647	ENSP00000368688	tetratricopeptide repeat domain 19; Mitochondrial protein required for formation of the mitochondrial complex III (PubMed-21278747). May also be required for the abcission step in cytokinesis, possibly regulating the ESCRT-III complex via its interaction with CHMP4B (PubMed-20208530). However, the involvement in cytokinesis requires additional experimental evidence	LYR motif containing 7; Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane	0.471
TTC19	SDHAF1	ENSP00000261647	ENSP00000368165	tetratricopeptide repeat domain 19; Mitochondrial protein required for formation of the mitochondrial complex III (PubMed-21278747). May also be required for the abcission step in cytokinesis, possibly regulating the ESCRT-III complex via its interaction with CHMP4B (PubMed-20208530). However, the involvement in cytokinesis requires additional experimental evidence	succinate dehydrogenase complex assembly factor 1; Plays an essential role in succinate dehydrogenase complex (SDH) assembly, a complex involved in complex II of the mitochondrial electron transport chain. Probably acts by participating in mitochondrial biosynthesis of iron-sulfur centers for complex II (Probable)	0.703
TTC19	UBC	ENSP00000261647	ENSP00000344818	tetratricopeptide repeat domain 19; Mitochondrial protein required for formation of the mitochondrial complex III (PubMed-21278747). May also be required for the abcission step in cytokinesis, possibly regulating the ESCRT-III complex via its interaction with CHMP4B (PubMed-20208530). However, the involvement in cytokinesis requires additional experimental evidence	ubiquitin C	0.645
UBC	LYRM7	ENSP00000344818	ENSP00000368688	ubiquitin C	LYR motif containing 7; Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane	0.483

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