PRNP protein (Homo sapiens) - STRING network view

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protein of unknown 3D structure

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Score

PRNP

prion protein (253 aa)

Predicted Functional Partners:

BCL2

0.990

STIP1

0.987

HSPA5

0.983

APP

0.983

NCAM1

0.982

RPSA

0.976

PLG

0.976

APLP2

0.932

GFAP

0.931

HSPA4

0.930

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APLP2	APP	ENSP00000263574	ENSP00000284981	amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity)	amyloid beta (A4) precursor protein	0.595
APLP2	NCAM1	ENSP00000263574	ENSP00000318472	amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity)	neural cell adhesion molecule 1	0.738
APLP2	PRNP	ENSP00000263574	ENSP00000368752	amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity)	prion protein	0.932
APP	APLP2	ENSP00000284981	ENSP00000263574	amyloid beta (A4) precursor protein	amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity)	0.595
APP	BCL2	ENSP00000284981	ENSP00000329623	amyloid beta (A4) precursor protein	B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)	0.425
APP	HSPA4	ENSP00000284981	ENSP00000302961	amyloid beta (A4) precursor protein	heat shock 70kDa protein 4	0.653
APP	HSPA5	ENSP00000284981	ENSP00000324173	amyloid beta (A4) precursor protein	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER	0.847
APP	NCAM1	ENSP00000284981	ENSP00000318472	amyloid beta (A4) precursor protein	neural cell adhesion molecule 1	0.772
APP	PLG	ENSP00000284981	ENSP00000308938	amyloid beta (A4) precursor protein	plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.923
APP	PRNP	ENSP00000284981	ENSP00000368752	amyloid beta (A4) precursor protein	prion protein	0.983
BCL2	APP	ENSP00000329623	ENSP00000284981	B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)	amyloid beta (A4) precursor protein	0.425
BCL2	HSPA4	ENSP00000329623	ENSP00000302961	B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)	heat shock 70kDa protein 4	0.582
BCL2	HSPA5	ENSP00000329623	ENSP00000324173	B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER	0.693
BCL2	NCAM1	ENSP00000329623	ENSP00000318472	B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)	neural cell adhesion molecule 1	0.566
BCL2	PRNP	ENSP00000329623	ENSP00000368752	B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)	prion protein	0.990
GFAP	NCAM1	ENSP00000253408	ENSP00000318472	glial fibrillary acidic protein	neural cell adhesion molecule 1	0.420
GFAP	PRNP	ENSP00000253408	ENSP00000368752	glial fibrillary acidic protein	prion protein	0.931
HSPA4	APP	ENSP00000302961	ENSP00000284981	heat shock 70kDa protein 4	amyloid beta (A4) precursor protein	0.653
HSPA4	BCL2	ENSP00000302961	ENSP00000329623	heat shock 70kDa protein 4	B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)	0.582
HSPA4	HSPA5	ENSP00000302961	ENSP00000324173	heat shock 70kDa protein 4	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER	0.825

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