node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADRA1A | ADRA1D | ENSP00000369960 | ENSP00000368766 | adrenoceptor alpha 1A | adrenoceptor alpha 1D; This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium | 0.955 |
ADRA1A | AGT | ENSP00000369960 | ENSP00000355627 | adrenoceptor alpha 1A | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | 0.911 |
ADRA1A | ARHGEF12 | ENSP00000369960 | ENSP00000380942 | adrenoceptor alpha 1A | Rho guanine nucleotide exchange factor (GEF) 12; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 | 0.967 |
ADRA1A | GNA11 | ENSP00000369960 | ENSP00000078429 | adrenoceptor alpha 1A | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | 0.957 |
ADRA1A | GNA13 | ENSP00000369960 | ENSP00000400717 | adrenoceptor alpha 1A | guanine nucleotide binding protein (G protein), alpha 13; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | 0.974 |
ADRA1A | GNAQ | ENSP00000369960 | ENSP00000286548 | adrenoceptor alpha 1A | guanine nucleotide binding protein (G protein), q polypeptide; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity) | 0.961 |
ADRA1A | NPFFR1 | ENSP00000369960 | ENSP00000277942 | adrenoceptor alpha 1A | neuropeptide FF receptor 1; Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | 0.912 |
ADRA1A | NPFFR2 | ENSP00000369960 | ENSP00000307822 | adrenoceptor alpha 1A | neuropeptide FF receptor 2; Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | 0.911 |
ADRA1A | RGS2 | ENSP00000369960 | ENSP00000235382 | adrenoceptor alpha 1A | regulator of G-protein signaling 2, 24kDa; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein | 0.961 |
ADRA1A | TBXA2R | ENSP00000369960 | ENSP00000393333 | adrenoceptor alpha 1A | thromboxane A2 receptor; Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase | 0.900 |
ADRA1D | ADRA1A | ENSP00000368766 | ENSP00000369960 | adrenoceptor alpha 1D; This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium | adrenoceptor alpha 1A | 0.955 |
ADRA1D | AGT | ENSP00000368766 | ENSP00000355627 | adrenoceptor alpha 1D; This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | 0.912 |
ADRA1D | ARHGEF12 | ENSP00000368766 | ENSP00000380942 | adrenoceptor alpha 1D; This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium | Rho guanine nucleotide exchange factor (GEF) 12; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 | 0.948 |
ADRA1D | GNA11 | ENSP00000368766 | ENSP00000078429 | adrenoceptor alpha 1D; This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium | guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C | 0.937 |
ADRA1D | GNA13 | ENSP00000368766 | ENSP00000400717 | adrenoceptor alpha 1D; This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium | guanine nucleotide binding protein (G protein), alpha 13; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | 0.951 |
ADRA1D | GNAQ | ENSP00000368766 | ENSP00000286548 | adrenoceptor alpha 1D; This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium | guanine nucleotide binding protein (G protein), q polypeptide; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity) | 0.952 |
ADRA1D | NPFFR1 | ENSP00000368766 | ENSP00000277942 | adrenoceptor alpha 1D; This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium | neuropeptide FF receptor 1; Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | 0.912 |
ADRA1D | NPFFR2 | ENSP00000368766 | ENSP00000307822 | adrenoceptor alpha 1D; This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium | neuropeptide FF receptor 2; Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system | 0.915 |
ADRA1D | RGS2 | ENSP00000368766 | ENSP00000235382 | adrenoceptor alpha 1D; This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium | regulator of G-protein signaling 2, 24kDa; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein | 0.911 |
ADRA1D | TBXA2R | ENSP00000368766 | ENSP00000393333 | adrenoceptor alpha 1D; This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium | thromboxane A2 receptor; Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase | 0.954 |