| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CLTC | TOM1L2 | ENSP00000269122 | ENSP00000368818 | clathrin, heavy chain (Hc); Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network | target of myb1-like 2 (chicken); Probable role in protein transport. May regulate growth factor-induced mitogenic signaling | 0.695 |
| CLTC | UBC | ENSP00000269122 | ENSP00000344818 | clathrin, heavy chain (Hc); Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network | ubiquitin C | 0.999 |
| RCN1 | SRXN1 | ENSP00000054950 | ENSP00000371388 | reticulocalbin 1, EF-hand calcium binding domain; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment | sulfiredoxin 1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase | 0.644 |
| RCN1 | SULT1A1 | ENSP00000054950 | ENSP00000321988 | reticulocalbin 1, EF-hand calcium binding domain; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk | 0.740 |
| RCN1 | TOM1L2 | ENSP00000054950 | ENSP00000368818 | reticulocalbin 1, EF-hand calcium binding domain; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment | target of myb1-like 2 (chicken); Probable role in protein transport. May regulate growth factor-induced mitogenic signaling | 0.907 |
| RCN1 | UBC | ENSP00000054950 | ENSP00000344818 | reticulocalbin 1, EF-hand calcium binding domain; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment | ubiquitin C | 0.761 |
| S100A4 | TOM1L2 | ENSP00000346294 | ENSP00000368818 | S100 calcium binding protein A4 | target of myb1-like 2 (chicken); Probable role in protein transport. May regulate growth factor-induced mitogenic signaling | 0.909 |
| S100A4 | UBC | ENSP00000346294 | ENSP00000344818 | S100 calcium binding protein A4 | ubiquitin C | 0.807 |
| SIN3A | TOM1L2 | ENSP00000353622 | ENSP00000368818 | SIN3 transcription regulator homolog A (yeast); Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA (By similarity). Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation | target of myb1-like 2 (chicken); Probable role in protein transport. May regulate growth factor-induced mitogenic signaling | 0.909 |
| SIN3A | UBC | ENSP00000353622 | ENSP00000344818 | SIN3 transcription regulator homolog A (yeast); Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA (By similarity). Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation | ubiquitin C | 0.945 |
| SRXN1 | RCN1 | ENSP00000371388 | ENSP00000054950 | sulfiredoxin 1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase | reticulocalbin 1, EF-hand calcium binding domain; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment | 0.644 |
| SRXN1 | SULT1A1 | ENSP00000371388 | ENSP00000321988 | sulfiredoxin 1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk | 0.924 |
| SRXN1 | TOM1L2 | ENSP00000371388 | ENSP00000368818 | sulfiredoxin 1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase | target of myb1-like 2 (chicken); Probable role in protein transport. May regulate growth factor-induced mitogenic signaling | 0.908 |
| SRXN1 | UBA2 | ENSP00000371388 | ENSP00000246548 | sulfiredoxin 1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase | ubiquitin-like modifier activating enzyme 2; The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 | 0.907 |
| SULT1A1 | RCN1 | ENSP00000321988 | ENSP00000054950 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk | reticulocalbin 1, EF-hand calcium binding domain; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment | 0.740 |
| SULT1A1 | SRXN1 | ENSP00000321988 | ENSP00000371388 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk | sulfiredoxin 1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase | 0.924 |
| SULT1A1 | TOM1L2 | ENSP00000321988 | ENSP00000368818 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk | target of myb1-like 2 (chicken); Probable role in protein transport. May regulate growth factor-induced mitogenic signaling | 0.883 |
| SULT1A1 | UBA2 | ENSP00000321988 | ENSP00000246548 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk | ubiquitin-like modifier activating enzyme 2; The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 | 0.906 |
| SULT1A1 | UBC | ENSP00000321988 | ENSP00000344818 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk | ubiquitin C | 0.483 |
| TOLLIP | TOM1L2 | ENSP00000314733 | ENSP00000368818 | toll interacting protein; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity | target of myb1-like 2 (chicken); Probable role in protein transport. May regulate growth factor-induced mitogenic signaling | 0.751 |
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