node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EBNA1BP2 | EIF6 | ENSP00000407323 | ENSP00000363559 | EBNA1 binding protein 2; Required for the processing of the 27S pre-rRNA (By similarity) | eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity | 0.950 |
EBNA1BP2 | NIP7 | ENSP00000407323 | ENSP00000254940 | EBNA1 binding protein 2; Required for the processing of the 27S pre-rRNA (By similarity) | nuclear import 7 homolog (S. cerevisiae); Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly | 0.995 |
EBNA1BP2 | NOP2 | ENSP00000407323 | ENSP00000382392 | EBNA1 binding protein 2; Required for the processing of the 27S pre-rRNA (By similarity) | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | 0.999 |
EBNA1BP2 | NSUN6 | ENSP00000407323 | ENSP00000366519 | EBNA1 binding protein 2; Required for the processing of the 27S pre-rRNA (By similarity) | NOP2/Sun domain family, member 6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) | 0.984 |
EBNA1BP2 | PAK1IP1 | ENSP00000407323 | ENSP00000368887 | EBNA1 binding protein 2; Required for the processing of the 27S pre-rRNA (By similarity) | PAK1 interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which have been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42 | 0.834 |
EBNA1BP2 | PES1 | ENSP00000407323 | ENSP00000346725 | EBNA1 binding protein 2; Required for the processing of the 27S pre-rRNA (By similarity) | pescadillo ribosomal biogenesis factor 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome | 0.994 |
EBNA1BP2 | RPF2 | ENSP00000407323 | ENSP00000402338 | EBNA1 binding protein 2; Required for the processing of the 27S pre-rRNA (By similarity) | ribosome production factor 2 homolog (S. cerevisiae) | 0.999 |
EBNA1BP2 | RSL24D1 | ENSP00000407323 | ENSP00000260443 | EBNA1 binding protein 2; Required for the processing of the 27S pre-rRNA (By similarity) | ribosomal L24 domain containing 1; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity) | 0.927 |
EBNA1BP2 | WDR12 | ENSP00000407323 | ENSP00000261015 | EBNA1 binding protein 2; Required for the processing of the 27S pre-rRNA (By similarity) | WD repeat domain 12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome | 0.995 |
EBNA1BP2 | WDR74 | ENSP00000407323 | ENSP00000278856 | EBNA1 binding protein 2; Required for the processing of the 27S pre-rRNA (By similarity) | WD repeat domain 74 | 0.975 |
EIF6 | EBNA1BP2 | ENSP00000363559 | ENSP00000407323 | eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity | EBNA1 binding protein 2; Required for the processing of the 27S pre-rRNA (By similarity) | 0.950 |
EIF6 | NIP7 | ENSP00000363559 | ENSP00000254940 | eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity | nuclear import 7 homolog (S. cerevisiae); Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly | 0.961 |
EIF6 | NOP2 | ENSP00000363559 | ENSP00000382392 | eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | 0.993 |
EIF6 | NSUN6 | ENSP00000363559 | ENSP00000366519 | eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity | NOP2/Sun domain family, member 6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) | 0.861 |
EIF6 | PAK1IP1 | ENSP00000363559 | ENSP00000368887 | eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity | PAK1 interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which have been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42 | 0.836 |
EIF6 | PES1 | ENSP00000363559 | ENSP00000346725 | eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity | pescadillo ribosomal biogenesis factor 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome | 0.971 |
EIF6 | RPF2 | ENSP00000363559 | ENSP00000402338 | eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity | ribosome production factor 2 homolog (S. cerevisiae) | 0.970 |
EIF6 | RSL24D1 | ENSP00000363559 | ENSP00000260443 | eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity | ribosomal L24 domain containing 1; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity) | 0.960 |
EIF6 | WDR12 | ENSP00000363559 | ENSP00000261015 | eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity | WD repeat domain 12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome | 0.934 |
EIF6 | WDR74 | ENSP00000363559 | ENSP00000278856 | eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity | WD repeat domain 74 | 0.958 |