node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKAP13 | ARHGAP44 | ENSP00000354718 | ENSP00000368994 | A kinase (PRKA) anchor protein 13 | Rho GTPase activating protein 44; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Acts as a GTPase activitor in vitro for CDC42 and RAC1 | 0.914 |
AKAP13 | ARHGEF12 | ENSP00000354718 | ENSP00000380942 | A kinase (PRKA) anchor protein 13 | Rho guanine nucleotide exchange factor (GEF) 12; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 | 0.917 |
AKAP13 | CDC42 | ENSP00000354718 | ENSP00000314458 | A kinase (PRKA) anchor protein 13 | cell division cycle 42 (GTP binding protein, 25kDa); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration | 0.961 |
AKAP13 | RAC3 | ENSP00000354718 | ENSP00000304283 | A kinase (PRKA) anchor protein 13 | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles | 0.956 |
AKAP13 | RHOA | ENSP00000354718 | ENSP00000400175 | A kinase (PRKA) anchor protein 13 | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.999 |
AKAP13 | RHOU | ENSP00000354718 | ENSP00000355652 | A kinase (PRKA) anchor protein 13 | ras homolog family member U; Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP- bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape | 0.921 |
ARHGAP44 | AKAP13 | ENSP00000368994 | ENSP00000354718 | Rho GTPase activating protein 44; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Acts as a GTPase activitor in vitro for CDC42 and RAC1 | A kinase (PRKA) anchor protein 13 | 0.914 |
ARHGAP44 | ARHGEF11 | ENSP00000368994 | ENSP00000357177 | Rho GTPase activating protein 44; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Acts as a GTPase activitor in vitro for CDC42 and RAC1 | Rho guanine nucleotide exchange factor (GEF) 11; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 | 0.914 |
ARHGAP44 | ARHGEF12 | ENSP00000368994 | ENSP00000380942 | Rho GTPase activating protein 44; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Acts as a GTPase activitor in vitro for CDC42 and RAC1 | Rho guanine nucleotide exchange factor (GEF) 12; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 | 0.914 |
ARHGAP44 | CDC42 | ENSP00000368994 | ENSP00000314458 | Rho GTPase activating protein 44; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Acts as a GTPase activitor in vitro for CDC42 and RAC1 | cell division cycle 42 (GTP binding protein, 25kDa); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration | 0.962 |
ARHGAP44 | ITSN1 | ENSP00000368994 | ENSP00000370719 | Rho GTPase activating protein 44; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Acts as a GTPase activitor in vitro for CDC42 and RAC1 | intersectin 1 (SH3 domain protein); Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1 | 0.910 |
ARHGAP44 | MCF2L | ENSP00000368994 | ENSP00000440374 | Rho GTPase activating protein 44; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Acts as a GTPase activitor in vitro for CDC42 and RAC1 | MCF.2 cell line derived transforming sequence-like | 0.941 |
ARHGAP44 | PLEKHG5 | ENSP00000368994 | ENSP00000366977 | Rho GTPase activating protein 44; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Acts as a GTPase activitor in vitro for CDC42 and RAC1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 5 | 0.916 |
ARHGAP44 | RAC3 | ENSP00000368994 | ENSP00000304283 | Rho GTPase activating protein 44; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Acts as a GTPase activitor in vitro for CDC42 and RAC1 | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles | 0.913 |
ARHGAP44 | RHOA | ENSP00000368994 | ENSP00000400175 | Rho GTPase activating protein 44; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Acts as a GTPase activitor in vitro for CDC42 and RAC1 | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.909 |
ARHGAP44 | RHOU | ENSP00000368994 | ENSP00000355652 | Rho GTPase activating protein 44; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Acts as a GTPase activitor in vitro for CDC42 and RAC1 | ras homolog family member U; Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP- bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape | 0.911 |
ARHGEF11 | ARHGAP44 | ENSP00000357177 | ENSP00000368994 | Rho guanine nucleotide exchange factor (GEF) 11; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 | Rho GTPase activating protein 44; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Acts as a GTPase activitor in vitro for CDC42 and RAC1 | 0.914 |
ARHGEF11 | ARHGEF12 | ENSP00000357177 | ENSP00000380942 | Rho guanine nucleotide exchange factor (GEF) 11; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 | Rho guanine nucleotide exchange factor (GEF) 12; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 | 0.927 |
ARHGEF11 | CDC42 | ENSP00000357177 | ENSP00000314458 | Rho guanine nucleotide exchange factor (GEF) 11; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 | cell division cycle 42 (GTP binding protein, 25kDa); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration | 0.987 |
ARHGEF11 | RAC3 | ENSP00000357177 | ENSP00000304283 | Rho guanine nucleotide exchange factor (GEF) 11; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles | 0.959 |