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STRINGSTRING
MAPRE1 MAPRE1 FAM167B FAM167B MAPRE3 MAPRE3 CNN1 CNN1 RC3H2 RC3H2 TMEM181 TMEM181 SPEF1 SPEF1 SPATA12 SPATA12 RC3H1 RC3H1 TEX35 TEX35 ANKRD20A1 ANKRD20A1
"SPEF1" - sperm flagellar 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPEF1sperm flagellar 1 (236 aa)    
Predicted Functional Partners:
MAPRE3
microtubule-associated protein, RP/EB family, member 3; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity) (281 aa)
       score_image     score_image   0.828
MAPRE1
microtubule-associated protein, RP/EB family, member 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (268 aa)
       score_image     score_image   0.772
CNN1
calponin 1, basic, smooth muscle; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity) (297 aa)
             score_image   0.752
RC3H2
ring finger and CCCH-type domains 2 (1191 aa)
             score_image   0.671
RC3H1
ring finger and CCCH-type domains 1; Represses ICOS function, an essential costimulatory receptor for follicular T-cells. May act as an ubiquitin ligase that regulates ubiquitin-dependent control of AU-rich mRNAs by AUF1/HNRPD and HUR/ELAVL1 (By similarity) (1133 aa)
             score_image   0.552
SPATA12
spermatogenesis associated 12 (190 aa)
             score_image   0.509
TEX35
testis expressed 35 (233 aa)
             score_image   0.509
ANKRD20A1
ankyrin repeat domain 20 family, member A1 (823 aa)
             score_image   0.502
FAM167B
family with sequence similarity 167, member B (163 aa)
             score_image   0.485
TMEM181
transmembrane protein 181; Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication (612 aa)
             score_image   0.467
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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