Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
CALCR CALCR PPP1R1C PPP1R1C EPHB2 EPHB2 PFN4 PFN4 CNTN2 CNTN2 GPR64 GPR64 MAN2B2 MAN2B2 TEDDM1 TEDDM1 CD52 CD52 CRISP1 CRISP1 WFDC2 WFDC2
"GPR64" - G protein-coupled receptor 64 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GPR64G protein-coupled receptor 64 (1017 aa)    
Predicted Functional Partners:
EPHB2
EPH receptor B2; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also i [...] (987 aa)
      score_image     score_image   0.818
CALCR
calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin (508 aa)
            score_image   0.683
MAN2B2
mannosidase, alpha, class 2B, member 2 (1009 aa)
            score_image   0.558
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C; Inhibitor of protein-phosphatase 1. Promotes cell growth and cell cycle progress at the G1/S transition. May increase cell susceptibility to TNF-induced apoptosis (109 aa)
            score_image   0.546
CD52
CD52 molecule; May play a role in carrying and orienting carbohydrate, as well as having a more specific role (61 aa)
            score_image   0.520
CRISP1
cysteine-rich secretory protein 1; May have a role in sperm-egg fusion and maturation (249 aa)
            score_image   0.510
CNTN2
contactin 2 (axonal); May play a role in the initial growth and guidance of axons. May be involved in cell adhesion (1040 aa)
            score_image   0.509
TEDDM1
transmembrane epididymal protein 1 (273 aa)
            score_image   0.509
PFN4
profilin family, member 4; Binds to actin and affects the structure of the cytoskeleton (By similarity) (129 aa)
            score_image   0.494
WFDC2
WAP four-disulfide core domain 2 (124 aa)
            score_image   0.470
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (37%)