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GALNT3 GALNT3 FGF23 FGF23 RGL2 RGL2 C9orf66 C9orf66 CALCA CALCA SAMD9 SAMD9 LEF1 LEF1 EEA1 EEA1 UBC UBC HERC6 HERC6 EPHB2 EPHB2
"SAMD9" - sterile alpha motif domain containing 9 in Homo sapiens
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SAMD9sterile alpha motif domain containing 9; May play a role in the inflammatory response to tissue injury and the control of extra-osseous calcification, acting as a downstream target of TNF-alpha signaling. Involved in the regulation of EGR1, in coordination with RGL2 (1589 aa)    
Predicted Functional Partners:
RGL2
ral guanine nucleotide dissociation stimulator-like 2; Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity) (777 aa)
            score_image   0.833
GALNT3
UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3); Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Probably glycosylates fibronectin in vivo. Glycosylates FGF23. Plays a central role in phosphate homeostasis (633 aa)
            score_image   0.811
CALCA
calcitonin-related polypeptide alpha; Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones (141 aa)
            score_image   0.786
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.623
FGF23
fibroblast growth factor 23; Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization (251 aa)
            score_image   0.585
EEA1
early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking (1411 aa)
        score_image   score_image   0.581
EPHB2
EPH receptor B2; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also i [...] (987 aa)
            score_image   0.440
LEF1
lymphoid enhancer-binding factor 1; Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 [...] (399 aa)
            score_image   0.440
C9orf66
chromosome 9 open reading frame 66 (295 aa)
            score_image   0.416
HERC6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 (1022 aa)
      score_image     score_image   0.406
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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