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OFD1 OFD1 SARM1 SARM1 CDKL5 CDKL5 NYX NYX RS1 RS1 PLIN2 PLIN2 GRK1 GRK1 CRX CRX TAAR5 TAAR5 PRPH2 PRPH2 RPE65 RPE65
"RS1" - retinoschisin 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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second shell of interactors
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experimentally determined
Predicted Interactions
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gene co-occurrence
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Score
RS1retinoschisin 1; May be active in cell adhesion processes during retinal development (224 aa)    
Predicted Functional Partners:
CRX
cone-rod homeobox; Binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, e.g. NRL and RX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors (299 aa)
      score_image     score_image   0.876
GRK1
G protein-coupled receptor kinase 1; Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (563 aa)
            score_image   0.749
TAAR5
trace amine associated receptor 5; Orphan receptor. Ligands are likely small molecules, either sharing some similarities with trace amine as, e.g. derivatives of indolamines (such as 5-methoxytryptamine) or of phenylethylamines (such as phenylethanolamine) or being any kind of metabolite of amino acids or biogenic amine neurotransmitters (337 aa)
            score_image   0.743
PLIN2
perilipin 2; May be involved in development and maintenance of adipose tissue (By similarity) (437 aa)
            score_image   0.589
CDKL5
cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2 (1030 aa)
            score_image   0.560
RPE65
retinal pigment epithelium-specific protein 65kDa; Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis- retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of th [...] (533 aa)
            score_image   0.540
PRPH2
peripherin 2 (retinal degeneration, slow); May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis (346 aa)
            score_image   0.511
NYX
nyctalopin (481 aa)
            score_image   0.505
SARM1
sterile alpha and TIR motif containing 1 (690 aa)
            score_image   0.501
OFD1
oral-facial-digital syndrome 1; Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis (By similarity) (1012 aa)
            score_image   0.489
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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