Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | GPR150 | G protein-coupled receptor 150; Orphan receptor (434 aa) | ||||||||||||
Predicted Functional Partners:
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 | PRTFDC1 | phosphoribosyl transferase domain containing 1; Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage (225 aa) |
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0.735 | ||||||||||
 | GPR139 | G protein-coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway (353 aa) |
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0.582 | ||||||||||
 | ITGA8 | integrin, alpha 8; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons (1063 aa) |
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0.543 | ||||||||||
 | GPR137C | G protein-coupled receptor 137C (429 aa) |
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0.522 | ||||||||||
 | GPR151 | G protein-coupled receptor 151; Orphan receptor (419 aa) |
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0.519 | ||||||||||
 | COX8C | cytochrome c oxidase subunit VIIIC; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport (72 aa) |
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0.480 | ||||||||||
 | HOXD11 | homeobox D11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (338 aa) |
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0.471 | ||||||||||
 | GPR137 | G protein-coupled receptor 137 (475 aa) |
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0.416 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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