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TBX3 TBX3 TBX2 TBX2 ZBTB16 ZBTB16 TBX4 TBX4 SKOR1 SKOR1 SMAD4 SMAD4 TLE1 TLE1 MAP2K5 MAP2K5 LBX1 LBX1 BTBD9 BTBD9 MEIS1 MEIS1
"SKOR1" - SKI family transcriptional corepressor 1 in Homo sapiens
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Predicted Interactions
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SKOR1SKI family transcriptional corepressor 1; Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling (965 aa)    
Predicted Functional Partners:
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG (770 aa)
        score_image   score_image   0.950
LBX1
ladybird homeobox 1; Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord (By similarity) (281 aa)
        score_image   score_image   0.906
ZBTB16
zinc finger and BTB domain containing 16; Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (673 aa)
        score_image   score_image   0.824
BTBD9
BTB (POZ) domain containing 9 (612 aa)
            score_image   0.819
MAP2K5
mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis (448 aa)
            score_image   0.748
SMAD4
SMAD family member 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. [...] (552 aa)
            score_image   0.716
TBX3
T-box 3; Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence (743 aa)
            score_image   0.700
TBX4
T-box 4; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation (545 aa)
            score_image   0.700
TBX2
T-box 2; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence (712 aa)
            score_image   0.700
MEIS1
Meis homeobox 1; Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias (390 aa)
            score_image   0.606
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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