node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BBOX1 | BTBD1 | ENSP00000263182 | ENSP00000261721 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; Catalyzes the formation of L-carnitine from gamma- butyrobetaine | BTB (POZ) domain containing 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins | 0.452 |
BBOX1 | BTBD2 | ENSP00000263182 | ENSP00000255608 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; Catalyzes the formation of L-carnitine from gamma- butyrobetaine | BTB (POZ) domain containing 2 | 0.406 |
BBOX1 | TRAT1 | ENSP00000263182 | ENSP00000295756 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; Catalyzes the formation of L-carnitine from gamma- butyrobetaine | T cell receptor associated transmembrane adaptor 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells | 0.825 |
BBOX1 | TRIM28 | ENSP00000263182 | ENSP00000253024 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; Catalyzes the formation of L-carnitine from gamma- butyrobetaine | tripartite motif containing 28; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitm [...] | 0.489 |
BBOX1 | TRIM5 | ENSP00000263182 | ENSP00000369373 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; Catalyzes the formation of L-carnitine from gamma- butyrobetaine | tripartite motif containing 5 | 0.720 |
BBOX1 | TRIM6 | ENSP00000263182 | ENSP00000369440 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; Catalyzes the formation of L-carnitine from gamma- butyrobetaine | tripartite motif containing 6 | 0.659 |
BTBD1 | BBOX1 | ENSP00000261721 | ENSP00000263182 | BTB (POZ) domain containing 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; Catalyzes the formation of L-carnitine from gamma- butyrobetaine | 0.452 |
BTBD1 | BTBD2 | ENSP00000261721 | ENSP00000255608 | BTB (POZ) domain containing 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins | BTB (POZ) domain containing 2 | 0.570 |
BTBD1 | TRIM5 | ENSP00000261721 | ENSP00000369373 | BTB (POZ) domain containing 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins | tripartite motif containing 5 | 0.939 |
BTBD1 | TRIM6 | ENSP00000261721 | ENSP00000369440 | BTB (POZ) domain containing 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins | tripartite motif containing 6 | 0.511 |
BTBD1 | UBC | ENSP00000261721 | ENSP00000344818 | BTB (POZ) domain containing 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins | ubiquitin C | 0.721 |
BTBD2 | BBOX1 | ENSP00000255608 | ENSP00000263182 | BTB (POZ) domain containing 2 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; Catalyzes the formation of L-carnitine from gamma- butyrobetaine | 0.406 |
BTBD2 | BTBD1 | ENSP00000255608 | ENSP00000261721 | BTB (POZ) domain containing 2 | BTB (POZ) domain containing 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins | 0.570 |
BTBD2 | TRIM5 | ENSP00000255608 | ENSP00000369373 | BTB (POZ) domain containing 2 | tripartite motif containing 5 | 0.939 |
BTBD2 | TRIM6 | ENSP00000255608 | ENSP00000369440 | BTB (POZ) domain containing 2 | tripartite motif containing 6 | 0.511 |
BTBD2 | UBC | ENSP00000255608 | ENSP00000344818 | BTB (POZ) domain containing 2 | ubiquitin C | 0.620 |
MYC | TRIM28 | ENSP00000367207 | ENSP00000253024 | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | tripartite motif containing 28; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitm [...] | 0.921 |
MYC | TRIM6 | ENSP00000367207 | ENSP00000369440 | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | tripartite motif containing 6 | 0.576 |
MYC | UBC | ENSP00000367207 | ENSP00000344818 | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | ubiquitin C | 0.999 |
TRAT1 | BBOX1 | ENSP00000295756 | ENSP00000263182 | T cell receptor associated transmembrane adaptor 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; Catalyzes the formation of L-carnitine from gamma- butyrobetaine | 0.825 |