node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CABP4 | S100G | ENSP00000324960 | ENSP00000369547 | calcium binding protein 4; Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages (By similarity) | S100 calcium binding protein G | 0.505 |
CALB1 | PVALB | ENSP00000265431 | ENSP00000216200 | calbindin 1, 28kDa; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase | parvalbumin; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions | 0.482 |
CALB1 | S100G | ENSP00000265431 | ENSP00000369547 | calbindin 1, 28kDa; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase | S100 calcium binding protein G | 0.759 |
CALB1 | TRPV5 | ENSP00000265431 | ENSP00000265310 | calbindin 1, 28kDa; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase | transient receptor potential cation channel, subfamily V, member 5; Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)- dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity) | 0.924 |
CALB1 | TRPV6 | ENSP00000265431 | ENSP00000352358 | calbindin 1, 28kDa; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase | transient receptor potential cation channel, subfamily V, member 6; Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin- dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. H [...] | 0.905 |
GEN1 | S100G | ENSP00000318977 | ENSP00000369547 | Gen endonuclease homolog 1 (Drosophila); Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation | S100 calcium binding protein G | 0.817 |
PTH | S100G | ENSP00000282091 | ENSP00000369547 | parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells | S100 calcium binding protein G | 0.505 |
PTH | SDF4 | ENSP00000282091 | ENSP00000353094 | parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells | stromal cell derived factor 4 | 0.507 |
PTH | TRPV5 | ENSP00000282091 | ENSP00000265310 | parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells | transient receptor potential cation channel, subfamily V, member 5; Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)- dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity) | 0.928 |
PTH | TRPV6 | ENSP00000282091 | ENSP00000352358 | parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells | transient receptor potential cation channel, subfamily V, member 6; Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin- dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. H [...] | 0.586 |
PTH | VDR | ENSP00000282091 | ENSP00000447173 | parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells | vitamin D (1,25- dihydroxyvitamin D3) receptor; Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis | 0.878 |
PVALB | CALB1 | ENSP00000216200 | ENSP00000265431 | parvalbumin; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions | calbindin 1, 28kDa; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase | 0.482 |
PVALB | S100G | ENSP00000216200 | ENSP00000369547 | parvalbumin; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions | S100 calcium binding protein G | 0.562 |
PVALB | SDF4 | ENSP00000216200 | ENSP00000353094 | parvalbumin; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions | stromal cell derived factor 4 | 0.871 |
S100G | CABP4 | ENSP00000369547 | ENSP00000324960 | S100 calcium binding protein G | calcium binding protein 4; Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages (By similarity) | 0.505 |
S100G | CALB1 | ENSP00000369547 | ENSP00000265431 | S100 calcium binding protein G | calbindin 1, 28kDa; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase | 0.759 |
S100G | GEN1 | ENSP00000369547 | ENSP00000318977 | S100 calcium binding protein G | Gen endonuclease homolog 1 (Drosophila); Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation | 0.817 |
S100G | PTH | ENSP00000369547 | ENSP00000282091 | S100 calcium binding protein G | parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells | 0.505 |
S100G | PVALB | ENSP00000369547 | ENSP00000216200 | S100 calcium binding protein G | parvalbumin; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions | 0.562 |
S100G | SDF4 | ENSP00000369547 | ENSP00000353094 | S100 calcium binding protein G | stromal cell derived factor 4 | 0.700 |