| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CUL1 | FBXO16 | ENSP00000326804 | ENSP00000369604 | cullin 1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate [...] | F-box protein 16; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation | 0.560 |
| CUL1 | SKP1 | ENSP00000326804 | ENSP00000231487 | cullin 1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate [...] | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.999 |
| CUL1 | UBE2S | ENSP00000326804 | ENSP00000264552 | cullin 1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate [...] | ubiquitin-conjugating enzyme E2S; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes ’Lys-11’-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating ’Lys-11’-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquit [...] | 0.718 |
| FAM133B | FBXO16 | ENSP00000398401 | ENSP00000369604 | family with sequence similarity 133, member B | F-box protein 16; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation | 0.563 |
| FAM133B | KRTAP5-5 | ENSP00000398401 | ENSP00000382584 | family with sequence similarity 133, member B | keratin associated protein 5-5; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins | 0.632 |
| FAM133B | OR10G7 | ENSP00000398401 | ENSP00000329689 | family with sequence similarity 133, member B | olfactory receptor, family 10, subfamily G, member 7; Odorant receptor (Potential) | 0.583 |
| FAM133B | OR13A1 | ENSP00000398401 | ENSP00000363522 | family with sequence similarity 133, member B | olfactory receptor, family 13, subfamily A, member 1; Odorant receptor (Potential) | 0.634 |
| FAM133B | OR2M4 | ENSP00000398401 | ENSP00000306688 | family with sequence similarity 133, member B | olfactory receptor, family 2, subfamily M, member 4; Odorant receptor (Potential) | 0.586 |
| FAM133B | TSPYL6 | ENSP00000398401 | ENSP00000417919 | family with sequence similarity 133, member B | TSPY-like 6 | 0.564 |
| FAM133B | ZDHHC20 | ENSP00000398401 | ENSP00000371905 | family with sequence similarity 133, member B | zinc finger, DHHC-type containing 20 | 0.582 |
| FBXO16 | CUL1 | ENSP00000369604 | ENSP00000326804 | F-box protein 16; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation | cullin 1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate [...] | 0.560 |
| FBXO16 | FAM133B | ENSP00000369604 | ENSP00000398401 | F-box protein 16; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation | family with sequence similarity 133, member B | 0.563 |
| FBXO16 | KRTAP5-5 | ENSP00000369604 | ENSP00000382584 | F-box protein 16; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation | keratin associated protein 5-5; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins | 0.624 |
| FBXO16 | OR10G7 | ENSP00000369604 | ENSP00000329689 | F-box protein 16; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation | olfactory receptor, family 10, subfamily G, member 7; Odorant receptor (Potential) | 0.581 |
| FBXO16 | OR13A1 | ENSP00000369604 | ENSP00000363522 | F-box protein 16; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation | olfactory receptor, family 13, subfamily A, member 1; Odorant receptor (Potential) | 0.630 |
| FBXO16 | OR2M4 | ENSP00000369604 | ENSP00000306688 | F-box protein 16; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation | olfactory receptor, family 2, subfamily M, member 4; Odorant receptor (Potential) | 0.584 |
| FBXO16 | SKP1 | ENSP00000369604 | ENSP00000231487 | F-box protein 16; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.746 |
| FBXO16 | TSPYL6 | ENSP00000369604 | ENSP00000417919 | F-box protein 16; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation | TSPY-like 6 | 0.561 |
| FBXO16 | UBE2S | ENSP00000369604 | ENSP00000264552 | F-box protein 16; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation | ubiquitin-conjugating enzyme E2S; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes ’Lys-11’-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating ’Lys-11’-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquit [...] | 0.608 |
| FBXO16 | ZDHHC20 | ENSP00000369604 | ENSP00000371905 | F-box protein 16; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation | zinc finger, DHHC-type containing 20 | 0.581 |
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