FAM50B protein (Homo sapiens) - STRING network view

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Score

FAM50B

family with sequence similarity 50, member B (325 aa)

Predicted Functional Partners:

AGMAT

0.666

HDAC2

0.644

MRPS16

0.644

MRPL54

0.644

ERAL1

0.644

XPR1

0.635

SSSCA1

0.618

MTFMT

0.592

GPATCH4

0.587

IL17C

0.582

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGMAT	FAM50B	ENSP00000364986	ENSP00000369625	agmatine ureohydrolase (agmatinase)	family with sequence similarity 50, member B	0.666
ERAL1	FAM50B	ENSP00000254928	ENSP00000369625	Era G-protein-like 1 (E. coli); Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3’ terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly	family with sequence similarity 50, member B	0.644
ERAL1	MRPS16	ENSP00000254928	ENSP00000362036	Era G-protein-like 1 (E. coli); Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3’ terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly	mitochondrial ribosomal protein S16	0.481
FAM50B	AGMAT	ENSP00000369625	ENSP00000364986	family with sequence similarity 50, member B	agmatine ureohydrolase (agmatinase)	0.666
FAM50B	ERAL1	ENSP00000369625	ENSP00000254928	family with sequence similarity 50, member B	Era G-protein-like 1 (E. coli); Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3’ terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly	0.644
FAM50B	GPATCH4	ENSP00000369625	ENSP00000396441	family with sequence similarity 50, member B	G patch domain containing 4	0.587
FAM50B	HDAC2	ENSP00000369625	ENSP00000430432	family with sequence similarity 50, member B	histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed o [...]	0.644
FAM50B	IL17C	ENSP00000369625	ENSP00000244241	family with sequence similarity 50, member B	interleukin 17C; Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic [...]	0.582
FAM50B	MRPL54	ENSP00000369625	ENSP00000331849	family with sequence similarity 50, member B	mitochondrial ribosomal protein L54	0.644
FAM50B	MRPS16	ENSP00000369625	ENSP00000362036	family with sequence similarity 50, member B	mitochondrial ribosomal protein S16	0.644
FAM50B	MTFMT	ENSP00000369625	ENSP00000220058	family with sequence similarity 50, member B	mitochondrial methionyl-tRNA formyltransferase; Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and an elongator species via an unknown mechanism (By similarity)	0.592
FAM50B	SSSCA1	ENSP00000369625	ENSP00000312318	family with sequence similarity 50, member B	Sjogren syndrome/scleroderma autoantigen 1; Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies	0.618
FAM50B	XPR1	ENSP00000369625	ENSP00000356562	family with sequence similarity 50, member B	xenotropic and polytropic retrovirus receptor 1; May function in G-protein coupled signal transduction (By similarity). Potential receptor for xenotropic and polytropic murine leukemia retroviruses	0.635
GPATCH4	FAM50B	ENSP00000396441	ENSP00000369625	G patch domain containing 4	family with sequence similarity 50, member B	0.587
GPATCH4	SSSCA1	ENSP00000396441	ENSP00000312318	G patch domain containing 4	Sjogren syndrome/scleroderma autoantigen 1; Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies	0.637
HDAC2	FAM50B	ENSP00000430432	ENSP00000369625	histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed o [...]	family with sequence similarity 50, member B	0.644
IL17C	FAM50B	ENSP00000244241	ENSP00000369625	interleukin 17C; Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic [...]	family with sequence similarity 50, member B	0.582
IL17C	XPR1	ENSP00000244241	ENSP00000356562	interleukin 17C; Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic [...]	xenotropic and polytropic retrovirus receptor 1; May function in G-protein coupled signal transduction (By similarity). Potential receptor for xenotropic and polytropic murine leukemia retroviruses	0.726
MRPL54	FAM50B	ENSP00000331849	ENSP00000369625	mitochondrial ribosomal protein L54	family with sequence similarity 50, member B	0.644
MRPL54	MRPS16	ENSP00000331849	ENSP00000362036	mitochondrial ribosomal protein L54	mitochondrial ribosomal protein S16	0.673

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