AVP protein (Homo sapiens) - STRING network view

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AVP

arginine vasopressin; Neurophysin 2 specifically binds vasopressin (164 aa)

Predicted Functional Partners:

CRH

0.997

EDN1

0.993

AVPR1A

0.993

OXTR

0.988

POMC

0.987

NPS

0.980

AQP2

0.975

KNG1

0.969

PTH

0.969

TRH

0.964

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQP2	AVP	ENSP00000199280	ENSP00000369647	aquaporin 2 (collecting duct); Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	0.975
AQP2	AVPR1A	ENSP00000199280	ENSP00000299178	aquaporin 2 (collecting duct); Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient	arginine vasopressin receptor 1A; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment	0.693
AQP2	CRH	ENSP00000199280	ENSP00000276571	aquaporin 2 (collecting duct); Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient	corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland	0.426
AQP2	KNG1	ENSP00000199280	ENSP00000265023	aquaporin 2 (collecting duct); Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient	kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...]	0.407
AQP2	PTH	ENSP00000199280	ENSP00000282091	aquaporin 2 (collecting duct); Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient	parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells	0.499
AVP	AQP2	ENSP00000369647	ENSP00000199280	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	aquaporin 2 (collecting duct); Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient	0.975
AVP	AVPR1A	ENSP00000369647	ENSP00000299178	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	arginine vasopressin receptor 1A; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment	0.993
AVP	CRH	ENSP00000369647	ENSP00000276571	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland	0.997
AVP	EDN1	ENSP00000369647	ENSP00000368683	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides	0.993
AVP	KNG1	ENSP00000369647	ENSP00000265023	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...]	0.969
AVP	NPS	ENSP00000369647	ENSP00000381105	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity)	0.980
AVP	OXTR	ENSP00000369647	ENSP00000324270	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol- calcium second messenger system	0.988
AVP	POMC	ENSP00000369647	ENSP00000264708	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol	0.987
AVP	PTH	ENSP00000369647	ENSP00000282091	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells	0.969
AVP	TRH	ENSP00000369647	ENSP00000303452	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes	0.964
AVPR1A	AQP2	ENSP00000299178	ENSP00000199280	arginine vasopressin receptor 1A; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment	aquaporin 2 (collecting duct); Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient	0.693
AVPR1A	AVP	ENSP00000299178	ENSP00000369647	arginine vasopressin receptor 1A; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	0.993
AVPR1A	EDN1	ENSP00000299178	ENSP00000368683	arginine vasopressin receptor 1A; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment	endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides	0.905
AVPR1A	KNG1	ENSP00000299178	ENSP00000265023	arginine vasopressin receptor 1A; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment	kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...]	0.907
AVPR1A	NPS	ENSP00000299178	ENSP00000381105	arginine vasopressin receptor 1A; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment	neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity)	0.939

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