Export your current network:
... as a bitmap image:
file format is 'PNG': portable network graphic
... as a high-resolution bitmap:
same PNG format, but resolution at 400 dpi
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as simple tabular text output:
TSV: tab separated values - can be opened in Excel
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and annotated functions of the network proteins
Browse interactions in tabular form:
node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CYGB | HBD | ENSP00000293230 | ENSP00000369654 | cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer | hemoglobin, delta; Involved in oxygen transport from the lung to the various peripheral tissues | 0.999 |
HBA2 | HBB | ENSP00000251595 | ENSP00000333994 | hemoglobin, alpha 2 | hemoglobin, beta | 0.997 |
HBA2 | HBD | ENSP00000251595 | ENSP00000369654 | hemoglobin, alpha 2 | hemoglobin, delta; Involved in oxygen transport from the lung to the various peripheral tissues | 0.983 |
HBA2 | HBE1 | ENSP00000251595 | ENSP00000292896 | hemoglobin, alpha 2 | hemoglobin, epsilon 1; The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin | 0.927 |
HBA2 | HBG2 | ENSP00000251595 | ENSP00000338082 | hemoglobin, alpha 2 | hemoglobin, gamma G; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains | 0.982 |
HBA2 | KLF1 | ENSP00000251595 | ENSP00000264834 | hemoglobin, alpha 2 | Kruppel-like factor 1 (erythroid); Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, a [...] | 0.436 |
HBB | HBA2 | ENSP00000333994 | ENSP00000251595 | hemoglobin, beta | hemoglobin, alpha 2 | 0.997 |
HBB | HBD | ENSP00000333994 | ENSP00000369654 | hemoglobin, beta | hemoglobin, delta; Involved in oxygen transport from the lung to the various peripheral tissues | 0.901 |
HBB | HBE1 | ENSP00000333994 | ENSP00000292896 | hemoglobin, beta | hemoglobin, epsilon 1; The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin | 0.901 |
HBB | HBG2 | ENSP00000333994 | ENSP00000338082 | hemoglobin, beta | hemoglobin, gamma G; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains | 0.956 |
HBB | KLF1 | ENSP00000333994 | ENSP00000264834 | hemoglobin, beta | Kruppel-like factor 1 (erythroid); Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, a [...] | 0.932 |
HBB | MAFF | ENSP00000333994 | ENSP00000345393 | hemoglobin, beta | v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian); Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. Since it lacks a putative transactivation domain, it may behave as a transcriptional repressor when it dimerize among himself. May also serve as a transcriptional activator by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. May be involved in the cellular stress response | 0.903 |
HBB | MAFG | ENSP00000333994 | ENSP00000350369 | hemoglobin, beta | v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian); Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF- E2. Activates glob [...] | 0.901 |
HBB | MAFK | ENSP00000333994 | ENSP00000344903 | hemoglobin, beta | v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian); Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor | 0.909 |
HBB | NFE2 | ENSP00000333994 | ENSP00000312436 | hemoglobin, beta | nuclear factor (erythroid-derived 2), 45kDa; Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron | 0.941 |
HBD | CYGB | ENSP00000369654 | ENSP00000293230 | hemoglobin, delta; Involved in oxygen transport from the lung to the various peripheral tissues | cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer | 0.999 |
HBD | HBA2 | ENSP00000369654 | ENSP00000251595 | hemoglobin, delta; Involved in oxygen transport from the lung to the various peripheral tissues | hemoglobin, alpha 2 | 0.983 |
HBD | HBB | ENSP00000369654 | ENSP00000333994 | hemoglobin, delta; Involved in oxygen transport from the lung to the various peripheral tissues | hemoglobin, beta | 0.901 |
HBD | HBE1 | ENSP00000369654 | ENSP00000292896 | hemoglobin, delta; Involved in oxygen transport from the lung to the various peripheral tissues | hemoglobin, epsilon 1; The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin | 0.901 |
HBD | HBG2 | ENSP00000369654 | ENSP00000338082 | hemoglobin, delta; Involved in oxygen transport from the lung to the various peripheral tissues | hemoglobin, gamma G; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains | 0.901 |
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