| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACBD7 | TMEM27 | ENSP00000367453 | ENSP00000369699 | acyl-CoA binding domain containing 7; Binds medium- and long-chain acyl-CoA esters | transmembrane protein 27; Regulator of SNARE complex function. Stimulator of beta cell replication | 0.619 |
| DBI | TMEM27 | ENSP00000440698 | ENSP00000369699 | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | transmembrane protein 27; Regulator of SNARE complex function. Stimulator of beta cell replication | 0.784 |
| HNF1A | TMEM27 | ENSP00000257555 | ENSP00000369699 | HNF1 homeobox A; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5’- GTTAATNATTAAC-3’ | transmembrane protein 27; Regulator of SNARE complex function. Stimulator of beta cell replication | 0.893 |
| SLC3A1 | SLC6A18 | ENSP00000260649 | ENSP00000323549 | solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule | solute carrier family 6, member 18; Functions as a sodium and chloride-dependent neutral amino acid transporter (By similarity) | 0.543 |
| SLC3A1 | SLC6A19 | ENSP00000260649 | ENSP00000305302 | solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule | solute carrier family 6 (neutral amino acid transporter), member 19; Transporter that mediates epithelial resorption of neutral amino acids across the apical membrane of epithelial cells in the kidney and intestine. It appears that leucine is the preferred substrate, but all large neutral non-aromatic L-amino acids bind to this transporter. Uptake of leucine is sodium- dependent. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity) | 0.632 |
| SLC3A1 | SLC6A20 | ENSP00000260649 | ENSP00000346298 | solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule | solute carrier family 6 (proline IMINO transporter), member 20; Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N- methylated amino acids. Involved in the transport of glycine | 0.448 |
| SLC3A1 | SLC7A9 | ENSP00000260649 | ENSP00000023064 | solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule | solute carrier family 7 (glycoprotein-associated amino acid transporter light chain, bo,+ system), member 9; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high- affinity reabsorption of cystine in the kidney tubule | 0.993 |
| SLC3A1 | TMEM27 | ENSP00000260649 | ENSP00000369699 | solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule | transmembrane protein 27; Regulator of SNARE complex function. Stimulator of beta cell replication | 0.729 |
| SLC6A15 | SLC7A9 | ENSP00000266682 | ENSP00000023064 | solute carrier family 6 (neutral amino acid transporter), member 15; Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1-1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent | solute carrier family 7 (glycoprotein-associated amino acid transporter light chain, bo,+ system), member 9; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high- affinity reabsorption of cystine in the kidney tubule | 0.488 |
| SLC6A15 | TMEM27 | ENSP00000266682 | ENSP00000369699 | solute carrier family 6 (neutral amino acid transporter), member 15; Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1-1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent | transmembrane protein 27; Regulator of SNARE complex function. Stimulator of beta cell replication | 0.619 |
| SLC6A18 | SLC3A1 | ENSP00000323549 | ENSP00000260649 | solute carrier family 6, member 18; Functions as a sodium and chloride-dependent neutral amino acid transporter (By similarity) | solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule | 0.543 |
| SLC6A18 | SLC7A9 | ENSP00000323549 | ENSP00000023064 | solute carrier family 6, member 18; Functions as a sodium and chloride-dependent neutral amino acid transporter (By similarity) | solute carrier family 7 (glycoprotein-associated amino acid transporter light chain, bo,+ system), member 9; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high- affinity reabsorption of cystine in the kidney tubule | 0.675 |
| SLC6A18 | TMEM27 | ENSP00000323549 | ENSP00000369699 | solute carrier family 6, member 18; Functions as a sodium and chloride-dependent neutral amino acid transporter (By similarity) | transmembrane protein 27; Regulator of SNARE complex function. Stimulator of beta cell replication | 0.845 |
| SLC6A19 | SLC3A1 | ENSP00000305302 | ENSP00000260649 | solute carrier family 6 (neutral amino acid transporter), member 19; Transporter that mediates epithelial resorption of neutral amino acids across the apical membrane of epithelial cells in the kidney and intestine. It appears that leucine is the preferred substrate, but all large neutral non-aromatic L-amino acids bind to this transporter. Uptake of leucine is sodium- dependent. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity) | solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule | 0.632 |
| SLC6A19 | SLC7A9 | ENSP00000305302 | ENSP00000023064 | solute carrier family 6 (neutral amino acid transporter), member 19; Transporter that mediates epithelial resorption of neutral amino acids across the apical membrane of epithelial cells in the kidney and intestine. It appears that leucine is the preferred substrate, but all large neutral non-aromatic L-amino acids bind to this transporter. Uptake of leucine is sodium- dependent. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity) | solute carrier family 7 (glycoprotein-associated amino acid transporter light chain, bo,+ system), member 9; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high- affinity reabsorption of cystine in the kidney tubule | 0.667 |
| SLC6A19 | TMEM27 | ENSP00000305302 | ENSP00000369699 | solute carrier family 6 (neutral amino acid transporter), member 19; Transporter that mediates epithelial resorption of neutral amino acids across the apical membrane of epithelial cells in the kidney and intestine. It appears that leucine is the preferred substrate, but all large neutral non-aromatic L-amino acids bind to this transporter. Uptake of leucine is sodium- dependent. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity) | transmembrane protein 27; Regulator of SNARE complex function. Stimulator of beta cell replication | 0.845 |
| SLC6A20 | SLC3A1 | ENSP00000346298 | ENSP00000260649 | solute carrier family 6 (proline IMINO transporter), member 20; Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N- methylated amino acids. Involved in the transport of glycine | solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule | 0.448 |
| SLC6A20 | SLC7A9 | ENSP00000346298 | ENSP00000023064 | solute carrier family 6 (proline IMINO transporter), member 20; Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N- methylated amino acids. Involved in the transport of glycine | solute carrier family 7 (glycoprotein-associated amino acid transporter light chain, bo,+ system), member 9; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high- affinity reabsorption of cystine in the kidney tubule | 0.612 |
| SLC6A20 | TMEM27 | ENSP00000346298 | ENSP00000369699 | solute carrier family 6 (proline IMINO transporter), member 20; Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N- methylated amino acids. Involved in the transport of glycine | transmembrane protein 27; Regulator of SNARE complex function. Stimulator of beta cell replication | 0.826 |
| SLC7A9 | SLC3A1 | ENSP00000023064 | ENSP00000260649 | solute carrier family 7 (glycoprotein-associated amino acid transporter light chain, bo,+ system), member 9; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high- affinity reabsorption of cystine in the kidney tubule | solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule | 0.993 |
Share
