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STRINGSTRING
CRHR2 CRHR2 UCN3 UCN3 UCN2 UCN2 IL10RB IL10RB CRHR1 CRHR1
"UCN3" - urocortin 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
UCN3urocortin 3 (161 aa)    
Predicted Functional Partners:
CRHR2
corticotropin releasing hormone receptor 2; This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (438 aa)
        score_image   score_image   0.831
CRHR1
corticotropin releasing hormone receptor 1; Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (444 aa)
        score_image   score_image   0.777
UCN2
urocortin 2; Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress (112 aa)
            score_image   0.583
IL10RB
interleukin 10 receptor, beta; Shared cell surface receptor required for the activation of five class 2 cytokines- IL10, IL22, IL26, IL28, and IFNL1 (325 aa)
        score_image       0.576
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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