node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COL11A1 | COL2A1 | ENSP00000359114 | ENSP00000369889 | collagen, type XI, alpha 1 | collagen, type II, alpha 1 | 0.928 |
COL11A1 | COL6A1 | ENSP00000359114 | ENSP00000355180 | collagen, type XI, alpha 1 | collagen, type VI, alpha 1; Collagen VI acts as a cell-binding protein | 0.912 |
COL11A1 | COL9A1 | ENSP00000359114 | ENSP00000349790 | collagen, type XI, alpha 1 | collagen, type IX, alpha 1 | 0.923 |
COL11A1 | COL9A2 | ENSP00000359114 | ENSP00000361834 | collagen, type XI, alpha 1 | collagen, type IX, alpha 2; Structural component of hyaline cartilage and vitreous of the eye | 0.921 |
COL11A1 | COL9A3 | ENSP00000359114 | ENSP00000341640 | collagen, type XI, alpha 1 | collagen, type IX, alpha 3; Structural component of hyaline cartilage and vitreous of the eye | 0.920 |
COL11A1 | COMP | ENSP00000359114 | ENSP00000222271 | collagen, type XI, alpha 1 | cartilage oligomeric matrix protein; May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BI [...] | 0.497 |
COL11A1 | ITGA2B | ENSP00000359114 | ENSP00000262407 | collagen, type XI, alpha 1 | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface | 0.809 |
COL11A1 | ITGB1 | ENSP00000359114 | ENSP00000303351 | collagen, type XI, alpha 1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.908 |
COL2A1 | COL11A1 | ENSP00000369889 | ENSP00000359114 | collagen, type II, alpha 1 | collagen, type XI, alpha 1 | 0.928 |
COL2A1 | COL6A1 | ENSP00000369889 | ENSP00000355180 | collagen, type II, alpha 1 | collagen, type VI, alpha 1; Collagen VI acts as a cell-binding protein | 0.966 |
COL2A1 | COL9A1 | ENSP00000369889 | ENSP00000349790 | collagen, type II, alpha 1 | collagen, type IX, alpha 1 | 0.966 |
COL2A1 | COL9A2 | ENSP00000369889 | ENSP00000361834 | collagen, type II, alpha 1 | collagen, type IX, alpha 2; Structural component of hyaline cartilage and vitreous of the eye | 0.966 |
COL2A1 | COL9A3 | ENSP00000369889 | ENSP00000341640 | collagen, type II, alpha 1 | collagen, type IX, alpha 3; Structural component of hyaline cartilage and vitreous of the eye | 0.964 |
COL2A1 | COMP | ENSP00000369889 | ENSP00000222271 | collagen, type II, alpha 1 | cartilage oligomeric matrix protein; May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BI [...] | 0.927 |
COL2A1 | ITGA2B | ENSP00000369889 | ENSP00000262407 | collagen, type II, alpha 1 | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface | 0.966 |
COL2A1 | ITGB1 | ENSP00000369889 | ENSP00000303351 | collagen, type II, alpha 1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.933 |
COL2A1 | SOX5 | ENSP00000369889 | ENSP00000398273 | collagen, type II, alpha 1 | SRY (sex determining region Y)-box 5 | 0.941 |
COL2A1 | SOX9 | ENSP00000369889 | ENSP00000245479 | collagen, type II, alpha 1 | SRY (sex determining region Y)-box 9; Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes | 0.977 |
COL6A1 | COL11A1 | ENSP00000355180 | ENSP00000359114 | collagen, type VI, alpha 1; Collagen VI acts as a cell-binding protein | collagen, type XI, alpha 1 | 0.912 |
COL6A1 | COL2A1 | ENSP00000355180 | ENSP00000369889 | collagen, type VI, alpha 1; Collagen VI acts as a cell-binding protein | collagen, type II, alpha 1 | 0.966 |