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STRINGSTRING
SOX5 SOX5 ITGA2B ITGA2B COL2A1 COL2A1 SOX9 SOX9 COL11A1 COL11A1 COMP COMP COL9A1 COL9A1 COL6A1 COL6A1 ITGB1 ITGB1 COL9A2 COL9A2 COL9A3 COL9A3
"COL2A1" - collagen, type II, alpha 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
COL2A1collagen, type II, alpha 1 (1487 aa)    
Predicted Functional Partners:
SOX9
SRY (sex determining region Y)-box 9; Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes (509 aa)
            score_image   0.977
COL9A1
collagen, type IX, alpha 1 (921 aa)
        score_image score_image score_image score_image 0.966
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface (1039 aa)
      score_image score_image score_image score_image   0.966
COL6A1
collagen, type VI, alpha 1; Collagen VI acts as a cell-binding protein (1028 aa)
      score_image score_image score_image score_image score_image 0.966
COL9A2
collagen, type IX, alpha 2; Structural component of hyaline cartilage and vitreous of the eye (689 aa)
        score_image score_image score_image score_image 0.966
COL9A3
collagen, type IX, alpha 3; Structural component of hyaline cartilage and vitreous of the eye (684 aa)
        score_image score_image score_image score_image 0.964
SOX5
SRY (sex determining region Y)-box 5 (763 aa)
            score_image   0.941
ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (798 aa)
          score_image score_image   0.933
COL11A1
collagen, type XI, alpha 1 (1806 aa)
          score_image score_image score_image 0.928
COMP
cartilage oligomeric matrix protein; May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BI [...] (757 aa)
      score_image score_image   score_image   0.927
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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