node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AARS | CARS | ENSP00000261772 | ENSP00000369897 | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity) | cysteinyl-tRNA synthetase | 0.929 |
AARS | EPRS | ENSP00000261772 | ENSP00000355890 | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity) | glutamyl-prolyl-tRNA synthetase | 0.942 |
AARS | FARS2 | ENSP00000261772 | ENSP00000274680 | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity) | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | 0.903 |
AARS | LARS | ENSP00000261772 | ENSP00000377954 | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity) | leucyl-tRNA synthetase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction- the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs | 0.998 |
AARS | MARS | ENSP00000261772 | ENSP00000262027 | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity) | methionyl-tRNA synthetase | 0.968 |
AARS | QARS | ENSP00000261772 | ENSP00000307567 | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity) | glutaminyl-tRNA synthetase | 0.992 |
AARS | TARS | ENSP00000261772 | ENSP00000265112 | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity) | threonyl-tRNA synthetase | 0.888 |
AARS | UBC | ENSP00000261772 | ENSP00000344818 | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity) | ubiquitin C | 0.961 |
AARS | YARS | ENSP00000261772 | ENSP00000362576 | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity) | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) | 0.922 |
CARS | AARS | ENSP00000369897 | ENSP00000261772 | cysteinyl-tRNA synthetase | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity) | 0.929 |
CARS | EPRS | ENSP00000369897 | ENSP00000355890 | cysteinyl-tRNA synthetase | glutamyl-prolyl-tRNA synthetase | 0.954 |
CARS | FARS2 | ENSP00000369897 | ENSP00000274680 | cysteinyl-tRNA synthetase | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | 0.827 |
CARS | LARS | ENSP00000369897 | ENSP00000377954 | cysteinyl-tRNA synthetase | leucyl-tRNA synthetase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction- the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs | 0.841 |
CARS | MARS | ENSP00000369897 | ENSP00000262027 | cysteinyl-tRNA synthetase | methionyl-tRNA synthetase | 0.896 |
CARS | QARS | ENSP00000369897 | ENSP00000307567 | cysteinyl-tRNA synthetase | glutaminyl-tRNA synthetase | 0.858 |
CARS | TARS | ENSP00000369897 | ENSP00000265112 | cysteinyl-tRNA synthetase | threonyl-tRNA synthetase | 0.831 |
CARS | UBC | ENSP00000369897 | ENSP00000344818 | cysteinyl-tRNA synthetase | ubiquitin C | 0.802 |
CARS | YARS | ENSP00000369897 | ENSP00000362576 | cysteinyl-tRNA synthetase | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) | 0.937 |
CARS | ZNF195 | ENSP00000369897 | ENSP00000382511 | cysteinyl-tRNA synthetase | zinc finger protein 195; May be involved in transcriptional regulation | 0.910 |
EPRS | AARS | ENSP00000355890 | ENSP00000261772 | glutamyl-prolyl-tRNA synthetase | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity) | 0.942 |