| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C2orf65 | EGFL6 | ENSP00000290536 | ENSP00000369976 | chromosome 2 open reading frame 65; Required for meiosis I progression during spermatogenesis (By similarity) | EGF-like-domain, multiple 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity) | 0.672 |
| CTPS2 | EGFL6 | ENSP00000352222 | ENSP00000369976 | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides | EGF-like-domain, multiple 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity) | 0.528 |
| CTPS2 | UPRT | ENSP00000352222 | ENSP00000362481 | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides | uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) | 0.459 |
| EGFL6 | C2orf65 | ENSP00000369976 | ENSP00000290536 | EGF-like-domain, multiple 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity) | chromosome 2 open reading frame 65; Required for meiosis I progression during spermatogenesis (By similarity) | 0.672 |
| EGFL6 | CTPS2 | ENSP00000369976 | ENSP00000352222 | EGF-like-domain, multiple 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity) | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides | 0.528 |
| EGFL6 | FRAS1 | ENSP00000369976 | ENSP00000264895 | EGF-like-domain, multiple 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity) | Fraser syndrome 1 | 0.639 |
| EGFL6 | FREM2 | ENSP00000369976 | ENSP00000280481 | EGF-like-domain, multiple 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity) | FRAS1 related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion | 0.507 |
| EGFL6 | PTTG1 | ENSP00000369976 | ENSP00000344936 | EGF-like-domain, multiple 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity) | pituitary tumor-transforming 1; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the tra [...] | 0.806 |
| EGFL6 | RBMX | ENSP00000369976 | ENSP00000359645 | EGF-like-domain, multiple 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity) | RNA binding motif protein, X-linked; RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates [...] | 0.504 |
| EGFL6 | RBMXL1 | ENSP00000369976 | ENSP00000318415 | EGF-like-domain, multiple 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity) | RNA binding motif protein, X-linked-like 1; RNA-binding protein which may be involved in pre-mRNA splicing (By similarity) | 0.521 |
| EGFL6 | UPRT | ENSP00000369976 | ENSP00000362481 | EGF-like-domain, multiple 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity) | uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) | 0.612 |
| EGFL6 | ZRSR1 | ENSP00000369976 | ENSP00000375133 | EGF-like-domain, multiple 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity) | zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1 | 0.592 |
| EGFL6 | ZRSR2 | ENSP00000369976 | ENSP00000303015 | EGF-like-domain, multiple 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity) | zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2; Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3’-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP- dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing | 0.622 |
| FRAS1 | EGFL6 | ENSP00000264895 | ENSP00000369976 | Fraser syndrome 1 | EGF-like-domain, multiple 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity) | 0.639 |
| FREM2 | EGFL6 | ENSP00000280481 | ENSP00000369976 | FRAS1 related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion | EGF-like-domain, multiple 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity) | 0.507 |
| PTTG1 | EGFL6 | ENSP00000344936 | ENSP00000369976 | pituitary tumor-transforming 1; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the tra [...] | EGF-like-domain, multiple 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity) | 0.806 |
| RBMX | EGFL6 | ENSP00000359645 | ENSP00000369976 | RNA binding motif protein, X-linked; RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates [...] | EGF-like-domain, multiple 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity) | 0.504 |
| RBMX | RBMXL1 | ENSP00000359645 | ENSP00000318415 | RNA binding motif protein, X-linked; RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates [...] | RNA binding motif protein, X-linked-like 1; RNA-binding protein which may be involved in pre-mRNA splicing (By similarity) | 0.597 |
| RBMX | UPRT | ENSP00000359645 | ENSP00000362481 | RNA binding motif protein, X-linked; RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates [...] | uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) | 0.497 |
| RBMX | ZRSR1 | ENSP00000359645 | ENSP00000375133 | RNA binding motif protein, X-linked; RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates [...] | zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1 | 0.493 |
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