ATXN3L protein (Homo sapiens) - STRING network view

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ATXN3L

ataxin 3-like; Deubiquitinating enzyme that cleaves both ’Lys-48’- linked and ’Lys-63’-linked poly-ubiquitin chains (in vitro) (355 aa)

Predicted Functional Partners:

VCP

0.664

SPATA5

0.664

SPATA5L1

0.653

ATAD2B

0.653

UBC

0.600

RPS27A

0.590

MPND

0.525

MIS18A

0.485

JOSD1

0.474

UCHL3

0.473

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD2B	ATXN3L	ENSP00000238789	ENSP00000369996	ATPase family, AAA domain containing 2B	ataxin 3-like; Deubiquitinating enzyme that cleaves both ’Lys-48’- linked and ’Lys-63’-linked poly-ubiquitin chains (in vitro)	0.653
ATAD2B	UBC	ENSP00000238789	ENSP00000344818	ATPase family, AAA domain containing 2B	ubiquitin C	0.581
ATXN3L	ATAD2B	ENSP00000369996	ENSP00000238789	ataxin 3-like; Deubiquitinating enzyme that cleaves both ’Lys-48’- linked and ’Lys-63’-linked poly-ubiquitin chains (in vitro)	ATPase family, AAA domain containing 2B	0.653
ATXN3L	JOSD1	ENSP00000369996	ENSP00000216039	ataxin 3-like; Deubiquitinating enzyme that cleaves both ’Lys-48’- linked and ’Lys-63’-linked poly-ubiquitin chains (in vitro)	Josephin domain containing 1; Has low protease activity towards poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme	0.474
ATXN3L	MIS18A	ENSP00000369996	ENSP00000290130	ataxin 3-like; Deubiquitinating enzyme that cleaves both ’Lys-48’- linked and ’Lys-63’-linked poly-ubiquitin chains (in vitro)	MIS18 kinetochore protein homolog A (S. pombe); Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis	0.485
ATXN3L	MPND	ENSP00000369996	ENSP00000262966	ataxin 3-like; Deubiquitinating enzyme that cleaves both ’Lys-48’- linked and ’Lys-63’-linked poly-ubiquitin chains (in vitro)	MPN domain containing; Probable protease (By similarity)	0.525
ATXN3L	RPS27A	ENSP00000369996	ENSP00000272317	ataxin 3-like; Deubiquitinating enzyme that cleaves both ’Lys-48’- linked and ’Lys-63’-linked poly-ubiquitin chains (in vitro)	ribosomal protein S27a	0.590
ATXN3L	SPATA5	ENSP00000369996	ENSP00000274008	ataxin 3-like; Deubiquitinating enzyme that cleaves both ’Lys-48’- linked and ’Lys-63’-linked poly-ubiquitin chains (in vitro)	spermatogenesis associated 5; May be involved in morphological and functional mitochondrial transformations during spermatogenesis (By similarity)	0.664
ATXN3L	SPATA5L1	ENSP00000369996	ENSP00000305494	ataxin 3-like; Deubiquitinating enzyme that cleaves both ’Lys-48’- linked and ’Lys-63’-linked poly-ubiquitin chains (in vitro)	spermatogenesis associated 5-like 1	0.653
ATXN3L	UBC	ENSP00000369996	ENSP00000344818	ataxin 3-like; Deubiquitinating enzyme that cleaves both ’Lys-48’- linked and ’Lys-63’-linked poly-ubiquitin chains (in vitro)	ubiquitin C	0.600
ATXN3L	UCHL3	ENSP00000369996	ENSP00000366819	ataxin 3-like; Deubiquitinating enzyme that cleaves both ’Lys-48’- linked and ’Lys-63’-linked poly-ubiquitin chains (in vitro)	ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase); Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards ’Lys-48’-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGF [...]	0.473
ATXN3L	VCP	ENSP00000369996	ENSP00000351777	ataxin 3-like; Deubiquitinating enzyme that cleaves both ’Lys-48’- linked and ’Lys-63’-linked poly-ubiquitin chains (in vitro)	valosin containing protein; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the e [...]	0.664
JOSD1	ATXN3L	ENSP00000216039	ENSP00000369996	Josephin domain containing 1; Has low protease activity towards poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme	ataxin 3-like; Deubiquitinating enzyme that cleaves both ’Lys-48’- linked and ’Lys-63’-linked poly-ubiquitin chains (in vitro)	0.474
JOSD1	UBC	ENSP00000216039	ENSP00000344818	Josephin domain containing 1; Has low protease activity towards poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme	ubiquitin C	0.992
MIS18A	ATXN3L	ENSP00000290130	ENSP00000369996	MIS18 kinetochore protein homolog A (S. pombe); Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis	ataxin 3-like; Deubiquitinating enzyme that cleaves both ’Lys-48’- linked and ’Lys-63’-linked poly-ubiquitin chains (in vitro)	0.485
MIS18A	UBC	ENSP00000290130	ENSP00000344818	MIS18 kinetochore protein homolog A (S. pombe); Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis	ubiquitin C	0.889
MPND	ATXN3L	ENSP00000262966	ENSP00000369996	MPN domain containing; Probable protease (By similarity)	ataxin 3-like; Deubiquitinating enzyme that cleaves both ’Lys-48’- linked and ’Lys-63’-linked poly-ubiquitin chains (in vitro)	0.525
MPND	UBC	ENSP00000262966	ENSP00000344818	MPN domain containing; Probable protease (By similarity)	ubiquitin C	0.481
MPND	UCHL3	ENSP00000262966	ENSP00000366819	MPN domain containing; Probable protease (By similarity)	ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase); Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards ’Lys-48’-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGF [...]	0.463
RPS27A	ATXN3L	ENSP00000272317	ENSP00000369996	ribosomal protein S27a	ataxin 3-like; Deubiquitinating enzyme that cleaves both ’Lys-48’- linked and ’Lys-63’-linked poly-ubiquitin chains (in vitro)	0.590

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