| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DHH | EBF4 | ENSP00000266991 | ENSP00000370022 | desert hedgehog; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development | early B-cell factor 4; Transcriptional factor which recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity) | 0.803 |
| DHH | NOTCH1 | ENSP00000266991 | ENSP00000277541 | desert hedgehog; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | 0.621 |
| DHH | NOTCH2 | ENSP00000266991 | ENSP00000256646 | desert hedgehog; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development | notch 2 | 0.500 |
| DHH | NOTCH3 | ENSP00000266991 | ENSP00000263388 | desert hedgehog; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development | notch 3; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity) | 0.510 |
| EBF4 | DHH | ENSP00000370022 | ENSP00000266991 | early B-cell factor 4; Transcriptional factor which recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity) | desert hedgehog; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development | 0.803 |
| EBF4 | IHH | ENSP00000370022 | ENSP00000295731 | early B-cell factor 4; Transcriptional factor which recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity) | Indian hedgehog; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification- may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity) | 0.803 |
| EBF4 | MESP2 | ENSP00000370022 | ENSP00000342392 | early B-cell factor 4; Transcriptional factor which recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity) | mesoderm posterior 2 homolog (mouse); Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. To [...] | 0.676 |
| EBF4 | NFE2L1 | ENSP00000370022 | ENSP00000354855 | early B-cell factor 4; Transcriptional factor which recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity) | nuclear factor (erythroid-derived 2)-like 1; Activates erythroid-specific, globin gene expression | 0.708 |
| EBF4 | NFE2L3 | ENSP00000370022 | ENSP00000056233 | early B-cell factor 4; Transcriptional factor which recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity) | nuclear factor (erythroid-derived 2)-like 3; Activates erythroid-specific, globin gene expression | 0.708 |
| EBF4 | NOTCH1 | ENSP00000370022 | ENSP00000277541 | early B-cell factor 4; Transcriptional factor which recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity) | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | 0.704 |
| EBF4 | NOTCH2 | ENSP00000370022 | ENSP00000256646 | early B-cell factor 4; Transcriptional factor which recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity) | notch 2 | 0.704 |
| EBF4 | NOTCH3 | ENSP00000370022 | ENSP00000263388 | early B-cell factor 4; Transcriptional factor which recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity) | notch 3; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity) | 0.704 |
| EBF4 | SHH | ENSP00000370022 | ENSP00000297261 | early B-cell factor 4; Transcriptional factor which recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity) | sonic hedgehog; Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development- signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- [...] | 0.803 |
| EBF4 | TMTC1 | ENSP00000370022 | ENSP00000442046 | early B-cell factor 4; Transcriptional factor which recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity) | transmembrane and tetratricopeptide repeat containing 1 | 0.748 |
| IHH | EBF4 | ENSP00000295731 | ENSP00000370022 | Indian hedgehog; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification- may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity) | early B-cell factor 4; Transcriptional factor which recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity) | 0.803 |
| IHH | NOTCH1 | ENSP00000295731 | ENSP00000277541 | Indian hedgehog; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification- may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity) | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | 0.717 |
| IHH | NOTCH2 | ENSP00000295731 | ENSP00000256646 | Indian hedgehog; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification- may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity) | notch 2 | 0.565 |
| IHH | NOTCH3 | ENSP00000295731 | ENSP00000263388 | Indian hedgehog; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification- may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity) | notch 3; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity) | 0.582 |
| MESP2 | EBF4 | ENSP00000342392 | ENSP00000370022 | mesoderm posterior 2 homolog (mouse); Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. To [...] | early B-cell factor 4; Transcriptional factor which recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity) | 0.676 |
| MESP2 | NOTCH1 | ENSP00000342392 | ENSP00000277541 | mesoderm posterior 2 homolog (mouse); Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. To [...] | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | 0.651 |
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