| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BID | BNC2 | ENSP00000318822 | ENSP00000370047 | BH3 interacting domain death agonist; The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2 | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | 0.419 |
| BIK | BNC2 | ENSP00000216115 | ENSP00000370047 | BCL2-interacting killer (apoptosis-inducing); Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | 0.412 |
| BNC2 | BID | ENSP00000370047 | ENSP00000318822 | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | BH3 interacting domain death agonist; The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2 | 0.419 |
| BNC2 | BIK | ENSP00000370047 | ENSP00000216115 | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | BCL2-interacting killer (apoptosis-inducing); Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX | 0.412 |
| BNC2 | CCDC171 | ENSP00000370047 | ENSP00000370077 | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | coiled-coil domain containing 171 | 0.412 |
| BNC2 | IRF6 | ENSP00000370047 | ENSP00000355988 | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | interferon regulatory factor 6; Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity) | 0.448 |
| BNC2 | RB1 | ENSP00000370047 | ENSP00000267163 | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV [...] | 0.567 |
| BNC2 | SKIV2L2 | ENSP00000370047 | ENSP00000230640 | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | superkiller viralicidic activity 2-like 2 (S. cerevisiae); May be involved in pre-mRNA splicing. Associated with the RNA exosome complex and involved in the 3’processing of the 7S pre-RNA to the mature 5.8S rRNA | 0.482 |
| BNC2 | SORCS1 | ENSP00000370047 | ENSP00000345964 | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | sortilin-related VPS10 domain containing receptor 1 | 0.533 |
| BNC2 | SPATA25 | ENSP00000370047 | ENSP00000361597 | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | spermatogenesis associated 25; May play a role in spermatogenesis | 0.412 |
| BNC2 | SRSF2 | ENSP00000370047 | ENSP00000353089 | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | serine/arginine-rich splicing factor 2; Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5’- and 3’-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre- mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5’- and 3’-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5’-AGSAGAGTA-3’ (S=C or G) or [...] | 0.759 |
| BNC2 | TRPV3 | ENSP00000370047 | ENSP00000461518 | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | transient receptor potential cation channel, subfamily V, member 3; Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling- TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) | 0.453 |
| CCDC171 | BNC2 | ENSP00000370077 | ENSP00000370047 | coiled-coil domain containing 171 | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | 0.412 |
| IRF6 | BNC2 | ENSP00000355988 | ENSP00000370047 | interferon regulatory factor 6; Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity) | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | 0.448 |
| RB1 | BNC2 | ENSP00000267163 | ENSP00000370047 | retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV [...] | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | 0.567 |
| SKIV2L2 | BNC2 | ENSP00000230640 | ENSP00000370047 | superkiller viralicidic activity 2-like 2 (S. cerevisiae); May be involved in pre-mRNA splicing. Associated with the RNA exosome complex and involved in the 3’processing of the 7S pre-RNA to the mature 5.8S rRNA | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | 0.482 |
| SORCS1 | BNC2 | ENSP00000345964 | ENSP00000370047 | sortilin-related VPS10 domain containing receptor 1 | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | 0.533 |
| SPATA25 | BNC2 | ENSP00000361597 | ENSP00000370047 | spermatogenesis associated 25; May play a role in spermatogenesis | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | 0.412 |
| SRSF2 | BNC2 | ENSP00000353089 | ENSP00000370047 | serine/arginine-rich splicing factor 2; Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5’- and 3’-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre- mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5’- and 3’-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5’-AGSAGAGTA-3’ (S=C or G) or [...] | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | 0.759 |
| TRPV3 | BNC2 | ENSP00000461518 | ENSP00000370047 | transient receptor potential cation channel, subfamily V, member 3; Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling- TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | 0.453 |
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