node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CASP1 | CASP4 | ENSP00000410076 | ENSP00000388566 | caspase 1, apoptosis-related cysteine peptidase; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis | caspase 4, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1 | 0.957 |
CASP1 | CASP8 | ENSP00000410076 | ENSP00000351273 | caspase 1, apoptosis-related cysteine peptidase; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis | caspase 8, apoptosis-related cysteine peptidase | 0.687 |
CASP1 | GZMB | ENSP00000410076 | ENSP00000216341 | caspase 1, apoptosis-related cysteine peptidase; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis | 0.569 |
CASP1 | SERPINB9 | ENSP00000410076 | ENSP00000370074 | caspase 1, apoptosis-related cysteine peptidase; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis | serpin peptidase inhibitor, clade B (ovalbumin), member 9; Granzyme B inhibitor | 0.765 |
CASP4 | CASP1 | ENSP00000388566 | ENSP00000410076 | caspase 4, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1 | caspase 1, apoptosis-related cysteine peptidase; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis | 0.957 |
CASP4 | CASP8 | ENSP00000388566 | ENSP00000351273 | caspase 4, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1 | caspase 8, apoptosis-related cysteine peptidase | 0.667 |
CASP4 | SERPINB9 | ENSP00000388566 | ENSP00000370074 | caspase 4, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1 | serpin peptidase inhibitor, clade B (ovalbumin), member 9; Granzyme B inhibitor | 0.639 |
CASP8 | CASP1 | ENSP00000351273 | ENSP00000410076 | caspase 8, apoptosis-related cysteine peptidase | caspase 1, apoptosis-related cysteine peptidase; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis | 0.687 |
CASP8 | CASP4 | ENSP00000351273 | ENSP00000388566 | caspase 8, apoptosis-related cysteine peptidase | caspase 4, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1 | 0.667 |
CASP8 | GCG | ENSP00000351273 | ENSP00000387662 | caspase 8, apoptosis-related cysteine peptidase | glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life | 0.423 |
CASP8 | GZMB | ENSP00000351273 | ENSP00000216341 | caspase 8, apoptosis-related cysteine peptidase | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis | 0.739 |
CASP8 | SERPINB9 | ENSP00000351273 | ENSP00000370074 | caspase 8, apoptosis-related cysteine peptidase | serpin peptidase inhibitor, clade B (ovalbumin), member 9; Granzyme B inhibitor | 0.757 |
CTSG | SERPINB9 | ENSP00000216336 | ENSP00000370074 | cathepsin G; Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe- CH2Cl and phenylmethylsulfonyl fluoride | serpin peptidase inhibitor, clade B (ovalbumin), member 9; Granzyme B inhibitor | 0.876 |
GCG | CASP8 | ENSP00000387662 | ENSP00000351273 | glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life | caspase 8, apoptosis-related cysteine peptidase | 0.423 |
GCG | SERPINB9 | ENSP00000387662 | ENSP00000370074 | glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life | serpin peptidase inhibitor, clade B (ovalbumin), member 9; Granzyme B inhibitor | 0.800 |
GZMB | CASP1 | ENSP00000216341 | ENSP00000410076 | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis | caspase 1, apoptosis-related cysteine peptidase; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis | 0.569 |
GZMB | CASP8 | ENSP00000216341 | ENSP00000351273 | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis | caspase 8, apoptosis-related cysteine peptidase | 0.739 |
GZMB | SERPINB9 | ENSP00000216341 | ENSP00000370074 | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis | serpin peptidase inhibitor, clade B (ovalbumin), member 9; Granzyme B inhibitor | 0.969 |
KIF3A | SERPINB9 | ENSP00000368020 | ENSP00000370074 | kinesin family member 3A; Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation (By similarity) | serpin peptidase inhibitor, clade B (ovalbumin), member 9; Granzyme B inhibitor | 0.800 |
NR2F1 | SERPINB9 | ENSP00000325819 | ENSP00000370074 | nuclear receptor subfamily 2, group F, member 1; Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5’-AGGTCA-3’ motif. Represses transcriptional activity of LHCG | serpin peptidase inhibitor, clade B (ovalbumin), member 9; Granzyme B inhibitor | 0.675 |