AMELX protein (Homo sapiens) - STRING network view

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AMELX

amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel (205 aa)

Predicted Functional Partners:

ENAM

0.861

AMBN

0.811

AMTN

0.758

TUFT1

0.747

CLCN4

0.746

MMP20

0.724

ASMT

0.681

MID1

0.670

NAP1L2

0.625

GPR143

0.610

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMBN	AMELX	ENSP00000313809	ENSP00000370088	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	0.811
AMBN	AMTN	ENSP00000313809	ENSP00000341013	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	amelotin; Could be a cell adhesion protein involved in the maturation of tooth enamel	0.860
AMBN	ENAM	ENSP00000313809	ENSP00000379383	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation	0.901
AMBN	MMP20	ENSP00000313809	ENSP00000260228	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	matrix metallopeptidase 20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix- aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation	0.870
AMBN	TUFT1	ENSP00000313809	ENSP00000357842	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	tuftelin 1; Involved in the mineralization and structural organization of enamel	0.759
AMELX	AMBN	ENSP00000370088	ENSP00000313809	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	0.811
AMELX	AMTN	ENSP00000370088	ENSP00000341013	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	amelotin; Could be a cell adhesion protein involved in the maturation of tooth enamel	0.758
AMELX	ASMT	ENSP00000370088	ENSP00000370639	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity	0.681
AMELX	CLCN4	ENSP00000370088	ENSP00000370213	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	chloride channel, voltage-sensitive 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons	0.746
AMELX	ENAM	ENSP00000370088	ENSP00000379383	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation	0.861
AMELX	GPR143	ENSP00000370088	ENSP00000417161	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	G protein-coupled receptor 143; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport	0.610
AMELX	MID1	ENSP00000370088	ENSP00000312678	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	midline 1 (Opitz/BBB syndrome); Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination	0.670
AMELX	MMP20	ENSP00000370088	ENSP00000260228	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	matrix metallopeptidase 20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix- aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation	0.724
AMELX	NAP1L2	ENSP00000370088	ENSP00000362616	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	nucleosome assembly protein 1-like 2; Acidic protein which may be involved in interactions with other proteins or DNA (By similarity)	0.625
AMELX	TUFT1	ENSP00000370088	ENSP00000357842	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	tuftelin 1; Involved in the mineralization and structural organization of enamel	0.747
AMTN	AMBN	ENSP00000341013	ENSP00000313809	amelotin; Could be a cell adhesion protein involved in the maturation of tooth enamel	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	0.860
AMTN	AMELX	ENSP00000341013	ENSP00000370088	amelotin; Could be a cell adhesion protein involved in the maturation of tooth enamel	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	0.758
AMTN	ENAM	ENSP00000341013	ENSP00000379383	amelotin; Could be a cell adhesion protein involved in the maturation of tooth enamel	enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation	0.860
AMTN	MMP20	ENSP00000341013	ENSP00000260228	amelotin; Could be a cell adhesion protein involved in the maturation of tooth enamel	matrix metallopeptidase 20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix- aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation	0.659
ASMT	AMELX	ENSP00000370639	ENSP00000370088	acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	0.681

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