Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
CTAGE8 CTAGE8 POTEG POTEG DEFB104A DEFB104A OR4Q3 OR4Q3 SERF1B SERF1B WFIKKN2 WFIKKN2 SMN2 SMN2 SMN1 SMN1 NAIP NAIP
"SERF1B" - small EDRK-rich factor 1B in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SERF1Bsmall EDRK-rich factor 1B (centromeric) (110 aa)    
Predicted Functional Partners:
SMN2
survival of motor neuron 2, centromeric (294 aa)
            score_image   0.702
SMN1
survival of motor neuron 1, telomeric; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs (294 aa)
            score_image   0.663
POTEG
POTE ankyrin domain family, member G (508 aa)
            score_image   0.554
DEFB104A
defensin, beta 104A; Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103 (72 aa)
            score_image   0.538
CTAGE8
CTAGE family, member 8 (777 aa)
            score_image   0.537
WFIKKN2
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin (By similarity) (576 aa)
            score_image   0.502
NAIP
NLR family, apoptosis inhibitory protein; Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at ’Asp-315’ and decreasing the rate of auto proteolysis at ’Asp-330’. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor- neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apopt [...] (1403 aa)
            score_image   0.500
OR4Q3
olfactory receptor, family 4, subfamily Q, member 3; Odorant receptor (Potential) (313 aa)
            score_image   0.468
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: medium (49%)