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STRINGSTRING
FOXF2 FOXF2 FOXC1 FOXC1 FOXQ1 FOXQ1 GMDS GMDS TSTA3 TSTA3 GMPPB GMPPB DPM1 DPM1 DPM2 DPM2 GMPPA GMPPA ALG1 ALG1 DPM3 DPM3
"GMDS" - GDP-mannose 4,6-dehydratase in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
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experimentally determined
Predicted Interactions
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fusion edge
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gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
GMDSGDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose (372 aa)    
Predicted Functional Partners:
TSTA3
tissue specific transplantation antigen P35B; Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction (321 aa)
score_image   score_image score_image score_image score_image score_image   0.997
GMPPB
GDP-mannose pyrophosphorylase B (387 aa)
score_image         score_image score_image   0.940
GMPPA
GDP-mannose pyrophosphorylase A (420 aa)
score_image         score_image score_image   0.925
ALG1
asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog (S. cerevisiae); Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER (464 aa)
score_image     score_image   score_image score_image   0.880
DPM1
dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O- mannosylation of proteins (260 aa)
score_image     score_image   score_image score_image   0.845
DPM3
dolichyl-phosphate mannosyltransferase polypeptide 3; Stabilizer subunit of the dolichol-phosphate-mannose synthase complex (122 aa)
          score_image     0.800
DPM2
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit; Regulates the biosynthesis of dolichol phosphate- mannose. Essential for the ER localization and stable expression of DPM1 (84 aa)
          score_image     0.800
FOXC1
forkhead box C1; Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Regulates FOXO1 through binding to a conserved element, 5’- GTAAACAAA-3’ in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (553 aa)
            score_image   0.749
FOXF2
forkhead box F2; Probable transcription activator for a number of lung- specific genes (444 aa)
            score_image   0.747
FOXQ1
forkhead box Q1; Plays a role in hair follicle differentiation (By similarity) (403 aa)
            score_image   0.744
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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