| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABCB1 | ATP12A | ENSP00000265724 | ENSP00000218548 | ATP-binding cassette, sub-family B (MDR/TAP), member 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells | ATPase, H+/K+ transporting, nongastric, alpha polypeptide; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues | 0.587 |
| ABCB1 | ATP4A | ENSP00000265724 | ENSP00000262623 | ATP-binding cassette, sub-family B (MDR/TAP), member 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells | ATPase, H+/K+ exchanging, alpha polypeptide; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach | 0.587 |
| ABCB1 | CLCN4 | ENSP00000265724 | ENSP00000370213 | ATP-binding cassette, sub-family B (MDR/TAP), member 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells | chloride channel, voltage-sensitive 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons | 0.551 |
| AMELX | ASMT | ENSP00000370088 | ENSP00000370639 | amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel | acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity | 0.681 |
| AMELX | CLCN4 | ENSP00000370088 | ENSP00000370213 | amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel | chloride channel, voltage-sensitive 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons | 0.746 |
| AMELX | MID1 | ENSP00000370088 | ENSP00000312678 | amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel | midline 1 (Opitz/BBB syndrome); Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination | 0.670 |
| AMELX | SLC25A6 | ENSP00000370088 | ENSP00000370808 | amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis | 0.606 |
| ASMT | AMELX | ENSP00000370639 | ENSP00000370088 | acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity | amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel | 0.681 |
| ASMT | CLCN4 | ENSP00000370639 | ENSP00000370213 | acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity | chloride channel, voltage-sensitive 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons | 0.622 |
| ASMT | SLC25A6 | ENSP00000370639 | ENSP00000370808 | acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis | 0.759 |
| ATP12A | ABCB1 | ENSP00000218548 | ENSP00000265724 | ATPase, H+/K+ transporting, nongastric, alpha polypeptide; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues | ATP-binding cassette, sub-family B (MDR/TAP), member 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells | 0.587 |
| ATP12A | ATP4A | ENSP00000218548 | ENSP00000262623 | ATPase, H+/K+ transporting, nongastric, alpha polypeptide; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues | ATPase, H+/K+ exchanging, alpha polypeptide; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach | 0.903 |
| ATP12A | CLCN4 | ENSP00000218548 | ENSP00000370213 | ATPase, H+/K+ transporting, nongastric, alpha polypeptide; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues | chloride channel, voltage-sensitive 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons | 0.530 |
| ATP12A | OSTM1 | ENSP00000218548 | ENSP00000193322 | ATPase, H+/K+ transporting, nongastric, alpha polypeptide; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues | osteopetrosis associated transmembrane protein 1; Required for osteoclast and melanocyte maturation and function (By similarity) | 0.439 |
| ATP4A | ABCB1 | ENSP00000262623 | ENSP00000265724 | ATPase, H+/K+ exchanging, alpha polypeptide; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach | ATP-binding cassette, sub-family B (MDR/TAP), member 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells | 0.587 |
| ATP4A | ATP12A | ENSP00000262623 | ENSP00000218548 | ATPase, H+/K+ exchanging, alpha polypeptide; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach | ATPase, H+/K+ transporting, nongastric, alpha polypeptide; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues | 0.903 |
| ATP4A | CLCN4 | ENSP00000262623 | ENSP00000370213 | ATPase, H+/K+ exchanging, alpha polypeptide; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach | chloride channel, voltage-sensitive 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons | 0.546 |
| ATP4A | OSTM1 | ENSP00000262623 | ENSP00000193322 | ATPase, H+/K+ exchanging, alpha polypeptide; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach | osteopetrosis associated transmembrane protein 1; Required for osteoclast and melanocyte maturation and function (By similarity) | 0.440 |
| CFL1 | CLCN4 | ENSP00000309629 | ENSP00000370213 | cofilin 1 (non-muscle); Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization | chloride channel, voltage-sensitive 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons | 0.690 |
| CLCN4 | ABCB1 | ENSP00000370213 | ENSP00000265724 | chloride channel, voltage-sensitive 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons | ATP-binding cassette, sub-family B (MDR/TAP), member 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells | 0.551 |
Share
