node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ESRRB | HNF4A | ENSP00000370270 | ENSP00000312987 | estrogen-related receptor beta; Nuclear receptor, may regulate ESR1 transcriptional activity | hepatocyte nuclear factor 4, alpha | 0.913 |
ESRRB | HNF4G | ENSP00000370270 | ENSP00000379701 | estrogen-related receptor beta; Nuclear receptor, may regulate ESR1 transcriptional activity | hepatocyte nuclear factor 4, gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha | 0.913 |
ESRRB | NANOG | ENSP00000370270 | ENSP00000229307 | estrogen-related receptor beta; Nuclear receptor, may regulate ESR1 transcriptional activity | Nanog homeobox; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5’-TAAT[GT][GT]-3’ or 5 [...] | 0.983 |
ESRRB | NCOA3 | ENSP00000370270 | ENSP00000361066 | estrogen-related receptor beta; Nuclear receptor, may regulate ESR1 transcriptional activity | nuclear receptor coactivator 3 | 0.927 |
ESRRB | NR0B2 | ENSP00000370270 | ENSP00000254227 | estrogen-related receptor beta; Nuclear receptor, may regulate ESR1 transcriptional activity | nuclear receptor subfamily 0, group B, member 2; Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1 | 0.913 |
ESRRB | NR1D1 | ENSP00000370270 | ENSP00000246672 | estrogen-related receptor beta; Nuclear receptor, may regulate ESR1 transcriptional activity | nuclear receptor subfamily 1, group D, member 1; Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1 transcription (By similarity). Possible receptor for triiodothyronine | 0.910 |
ESRRB | NR4A1 | ENSP00000370270 | ENSP00000353427 | estrogen-related receptor beta; Nuclear receptor, may regulate ESR1 transcriptional activity | nuclear receptor subfamily 4, group A, member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5’- AAAAGGTCA-3’ (By similarity). May inhibit NF-kappa-B transactivation of IL2 | 0.915 |
ESRRB | NR4A2 | ENSP00000370270 | ENSP00000344479 | estrogen-related receptor beta; Nuclear receptor, may regulate ESR1 transcriptional activity | nuclear receptor subfamily 4, group A, member 2; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity) | 0.913 |
ESRRB | NRBP1 | ENSP00000370270 | ENSP00000233557 | estrogen-related receptor beta; Nuclear receptor, may regulate ESR1 transcriptional activity | nuclear receptor binding protein 1; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication | 0.912 |
ESRRB | RORB | ENSP00000370270 | ENSP00000366093 | estrogen-related receptor beta; Nuclear receptor, may regulate ESR1 transcriptional activity | RAR-related orphan receptor B; Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells. Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5’-AGGTCA-3’ in the OPN1SW promoter (By similarity) | 0.913 |
HNF4A | ESRRB | ENSP00000312987 | ENSP00000370270 | hepatocyte nuclear factor 4, alpha | estrogen-related receptor beta; Nuclear receptor, may regulate ESR1 transcriptional activity | 0.913 |
HNF4A | HNF4G | ENSP00000312987 | ENSP00000379701 | hepatocyte nuclear factor 4, alpha | hepatocyte nuclear factor 4, gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha | 0.901 |
HNF4A | NANOG | ENSP00000312987 | ENSP00000229307 | hepatocyte nuclear factor 4, alpha | Nanog homeobox; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5’-TAAT[GT][GT]-3’ or 5 [...] | 0.505 |
HNF4A | NCOA3 | ENSP00000312987 | ENSP00000361066 | hepatocyte nuclear factor 4, alpha | nuclear receptor coactivator 3 | 0.408 |
HNF4A | NR0B2 | ENSP00000312987 | ENSP00000254227 | hepatocyte nuclear factor 4, alpha | nuclear receptor subfamily 0, group B, member 2; Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1 | 0.993 |
HNF4A | NR1D1 | ENSP00000312987 | ENSP00000246672 | hepatocyte nuclear factor 4, alpha | nuclear receptor subfamily 1, group D, member 1; Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1 transcription (By similarity). Possible receptor for triiodothyronine | 0.910 |
HNF4A | NR4A1 | ENSP00000312987 | ENSP00000353427 | hepatocyte nuclear factor 4, alpha | nuclear receptor subfamily 4, group A, member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5’- AAAAGGTCA-3’ (By similarity). May inhibit NF-kappa-B transactivation of IL2 | 0.914 |
HNF4A | NR4A2 | ENSP00000312987 | ENSP00000344479 | hepatocyte nuclear factor 4, alpha | nuclear receptor subfamily 4, group A, member 2; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity) | 0.911 |
HNF4A | NRBP1 | ENSP00000312987 | ENSP00000233557 | hepatocyte nuclear factor 4, alpha | nuclear receptor binding protein 1; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication | 0.900 |
HNF4A | RORB | ENSP00000312987 | ENSP00000366093 | hepatocyte nuclear factor 4, alpha | RAR-related orphan receptor B; Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells. Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5’-AGGTCA-3’ in the OPN1SW promoter (By similarity) | 0.905 |