SELO protein (Homo sapiens) - STRING network view

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[Homology]

Score

SELO

selenoprotein O (669 aa)

Predicted Functional Partners:

SELM

0.908

SELK

0.896

SELT

0.828

VIMP

0.812

SEPN1

0.810

MSRB1

0.755

SEP15

0.752

TXNRD3

0.748

EPT1

0.700

TXNRD1

0.684

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EPT1	SELK	ENSP00000260585	ENSP00000418813	ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific); Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via ’Kennedy’ pathway	selenoprotein K	0.550
EPT1	SELM	ENSP00000260585	ENSP00000383155	ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific); Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via ’Kennedy’ pathway	selenoprotein M precursor ; May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation (By similarity)	0.471
EPT1	SELO	ENSP00000260585	ENSP00000370288	ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific); Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via ’Kennedy’ pathway	selenoprotein O	0.700
EPT1	SELT	ENSP00000260585	ENSP00000418910	ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific); Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via ’Kennedy’ pathway	selenoprotein T precursor	0.659
EPT1	SEP15	ENSP00000260585	ENSP00000328729	ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific); Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via ’Kennedy’ pathway	15 kDa selenoprotein isoform 1 precursor ; May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum (By similarity)	0.427
EPT1	SEPN1	ENSP00000260585	ENSP00000355141	ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific); Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via ’Kennedy’ pathway	selenoprotein N, 1	0.655
EPT1	TXNRD3	ENSP00000260585	ENSP00000430031	ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific); Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via ’Kennedy’ pathway	thioredoxin reductase 3; Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity)	0.435
EPT1	VIMP	ENSP00000260585	ENSP00000381282	ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific); Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via ’Kennedy’ pathway	VCP-interacting membrane protein; Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination	0.756
MSRB1	SELK	ENSP00000355084	ENSP00000418813	methionine sulfoxide reductase B1	selenoprotein K	0.653
MSRB1	SELO	ENSP00000355084	ENSP00000370288	methionine sulfoxide reductase B1	selenoprotein O	0.755
MSRB1	SELT	ENSP00000355084	ENSP00000418910	methionine sulfoxide reductase B1	selenoprotein T precursor	0.630
MSRB1	SEP15	ENSP00000355084	ENSP00000328729	methionine sulfoxide reductase B1	15 kDa selenoprotein isoform 1 precursor ; May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum (By similarity)	0.682
MSRB1	SEPN1	ENSP00000355084	ENSP00000355141	methionine sulfoxide reductase B1	selenoprotein N, 1	0.457
MSRB1	TXNRD1	ENSP00000355084	ENSP00000434516	methionine sulfoxide reductase B1	thioredoxin reductase 1	0.730
MSRB1	TXNRD3	ENSP00000355084	ENSP00000430031	methionine sulfoxide reductase B1	thioredoxin reductase 3; Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity)	0.759
MSRB1	VIMP	ENSP00000355084	ENSP00000381282	methionine sulfoxide reductase B1	VCP-interacting membrane protein; Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination	0.756
SELK	EPT1	ENSP00000418813	ENSP00000260585	selenoprotein K	ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific); Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via ’Kennedy’ pathway	0.550
SELK	MSRB1	ENSP00000418813	ENSP00000355084	selenoprotein K	methionine sulfoxide reductase B1	0.653
SELK	SELM	ENSP00000418813	ENSP00000383155	selenoprotein K	selenoprotein M precursor ; May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation (By similarity)	0.841
SELK	SELO	ENSP00000418813	ENSP00000370288	selenoprotein K	selenoprotein O	0.896

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