Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
IKZF5 IKZF5 RAI2 RAI2 SCRT1 SCRT1 SCRT2 SCRT2 SGTB SGTB DCLK1 DCLK1 GET4 GET4 ASNA1 ASNA1 CLPB CLPB UBC UBC HSPA8 HSPA8
"SGTB" - small glutamine-rich tetratricopeptide repeat in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SGTBsmall glutamine-rich tetratricopeptide repeat (TPR)-containing, beta; Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity (By similarity) (304 aa)    
Predicted Functional Partners:
GET4
golgi to ER traffic protein 4 homolog (S. cerevisiae); Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40- it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting (327 aa)
      score_image score_image   score_image   0.897
IKZF5
IKAROS family zinc finger 5 (Pegasus); DNA-binding protein that binds to the 5’GNNTGTNG-3’ core sequence. Transcriptional repressor (419 aa)
        score_image   score_image   0.863
ASNA1
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial); ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane pro [...] (348 aa)
      score_image score_image   score_image   0.839
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.766
CLPB
ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process (707 aa)
      score_image score_image   score_image   0.747
RAI2
retinoic acid induced 2 (530 aa)
        score_image       0.717
DCLK1
doublecortin-like kinase 1; Probable kinase that may be involved in a calcium- signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system (729 aa)
        score_image       0.684
SCRT1
scratch homolog 1, zinc finger protein (Drosophila); Transcriptional repressor that binds E-box motif CAGGTG. Can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal differentiation (348 aa)
        score_image       0.682
SCRT2
scratch homolog 2, zinc finger protein (Drosophila); May be involved in transcriptional regulation (307 aa)
        score_image       0.682
HSPA8
heat shock 70kDa protein 8; Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (646 aa)
score_image     score_image score_image   score_image   0.631
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (27%)