node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMOT | MPDZ | ENSP00000361027 | ENSP00000370410 | angiomotin; Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions | multiple PDZ domain protein | 0.988 |
AMOT | MPP5 | ENSP00000361027 | ENSP00000261681 | angiomotin; Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions | membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity) | 0.998 |
CLDN1 | CLDN19 | ENSP00000295522 | ENSP00000296387 | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | claudin 19; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) | 0.803 |
CLDN1 | CLDN5 | ENSP00000295522 | ENSP00000384554 | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) | 0.914 |
CLDN1 | CLDN8 | ENSP00000295522 | ENSP00000286809 | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | claudin 8; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) | 0.815 |
CLDN1 | F11R | ENSP00000295522 | ENSP00000289779 | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | F11 receptor; Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus | 0.954 |
CLDN1 | MPDZ | ENSP00000295522 | ENSP00000370410 | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | multiple PDZ domain protein | 0.943 |
CLDN1 | MPP5 | ENSP00000295522 | ENSP00000261681 | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity) | 0.438 |
CLDN19 | CLDN1 | ENSP00000296387 | ENSP00000295522 | claudin 19; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | 0.803 |
CLDN19 | CLDN5 | ENSP00000296387 | ENSP00000384554 | claudin 19; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) | claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) | 0.808 |
CLDN19 | CLDN8 | ENSP00000296387 | ENSP00000286809 | claudin 19; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) | claudin 8; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) | 0.811 |
CLDN19 | MPDZ | ENSP00000296387 | ENSP00000370410 | claudin 19; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) | multiple PDZ domain protein | 0.912 |
CLDN5 | CLDN1 | ENSP00000384554 | ENSP00000295522 | claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | 0.914 |
CLDN5 | CLDN19 | ENSP00000384554 | ENSP00000296387 | claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) | claudin 19; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) | 0.808 |
CLDN5 | CLDN8 | ENSP00000384554 | ENSP00000286809 | claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) | claudin 8; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) | 0.811 |
CLDN5 | F11R | ENSP00000384554 | ENSP00000289779 | claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) | F11 receptor; Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus | 0.418 |
CLDN5 | MPDZ | ENSP00000384554 | ENSP00000370410 | claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) | multiple PDZ domain protein | 0.990 |
CLDN8 | CLDN1 | ENSP00000286809 | ENSP00000295522 | claudin 8; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) | claudin 1; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells | 0.815 |
CLDN8 | CLDN19 | ENSP00000286809 | ENSP00000296387 | claudin 8; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) | claudin 19; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) | 0.811 |
CLDN8 | CLDN5 | ENSP00000286809 | ENSP00000384554 | claudin 8; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) | claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) | 0.811 |